Recombinant Anti-KCNH2 Vesicular Antibody, EV Displayed (VS-0425-YC559)

CAT#: VS-0425-YC559

The Recombinant Anti-KCNH2 Vesicular Antibody, EV Displayed (VS-0425-YC559) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to KCNH2-expressed cells or tissues. KCNH2 is a voltage-activated potassium channel related to arrhythmias like long QT syndrome.

Gene Expression
Figure 1 RNA cell line category: Group enriched (K-562, NB-4, SH-SY5Y)

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • KCNH2
  • Host Animal
  • Mouse
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Potassium voltage-gated channel subfamily H member 2
  • Biological Process
  • Ion transport, Potassium transport, Transport
  • Molecular Function
  • Ion channel, Potassium channel, Voltage-gated channel
  • Introduction
  • This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.
  • Alternative Names
  • erg1, HERG, Kv11.1, LQT2
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CAT Product Name Application Type
HPAB-0475-FY Mouse Anti-KCNH2 Recombinant Antibody (HPAB-0475-FY) IF, ELISA Mouse IgG
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