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KCNH2

Anti-KCNH2 Products

Mouse Anti-KCNH2 Recombinant Antibody (HPAB-0475-FY) (HPAB-0475-FY)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IF, ELISA
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Mouse Anti-KCNH2 Recombinant Antibody; scFv Fragment (HPAB-0475-FY-S(P)) (HPAB-0475-FY-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: IF, ELISA
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Mouse Anti-KCNH2 Recombinant Antibody; Fab Fragment (HPAB-0475-FY-F(E)) (HPAB-0475-FY-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: IF, ELISA
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Recombinant Anti-KCNH2 Vesicular Antibody, EV Displayed (VS-0425-YC559) (VS-0425-YC559)
- Species Reactivity: Human
- Target: KCNH2
- Host Animal: Mouse
- Application: ELISA, FC, Cell-uptake
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For Research Use Only. Not For Clinical Use.

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Transporters, Voltage-gated ion channels

Predicted location

Membrane

Single cell type specificity

Group enriched (Bipolar cells, Cardiomyocytes, Erythroid cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (K-562, NB-4, SH-SY5Y)

Interaction

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits (PubMed:27916661). Interacts with DNAJB12 and DNAJB14; chaperones DNAJB12 and DNAJB14 promote tetramerization (PubMed:27916661). Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3 (By similarity). Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2 (PubMed:9230439, PubMed:10219239). Interacts with CANX (PubMed:16361248). The core-glycosylated, but not the fully glycosylated form interacts with RNF207 (PubMed:25281747). Interacts with NDFIP1 and NDFIP2 (PubMed:26363003).

Molecular function

Ion channel, Potassium channel, Voltage-gated channel

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