Recombinant Anti-Kel Vesicular Antibody, EV Displayed (VS-0425-YC701) (CAT#: VS-0425-YC701)
The Recombinant Anti-Kel Vesicular Antibody, EV Displayed (VS-0425-YC701) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to Kel-expressed cells or tissues. Kel is a polymorphic transmembrane glycoprotein associated with the Kell blood group, similar to neprilysin family members.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64442/1848_C11_12_cr5abb8a20c9b63_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64442/1848_C11_12_cr5abb8a20c9b63_selected.jpg
Figure 2 RNA cell line category: Group enriched (HEL, K-562)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197993-KEL
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197993-KEL
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- Kel
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Kell metallo-endopeptidase (Kell blood group)
- Molecular Function
- Blood group antigen, Hydrolase, Metalloprotease, Protease
- Cellular Localization
- Golgi apparatus, Plasma membrane, Nucleoplasm, Cytosol
- Introduction
- This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.
- Alternative Names
- CD238, ECE3
- Gene ID
- 3792
- UniProt ID
- P23276
Downloads
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IgG Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1373CQ | Human Anti-Kel Recombinant Antibody (clone MIMA-8) | FC | Human IgG1 |
| VS2-QX42 | Mouse Anti-KEL Recombinant Antibody (clone BRIC 18) | Haemagglutination | Mouse IgG2a, κ |
| VS2-QX43 | Mouse Anti-KEL Recombinant Antibody (clone BRIC 68) | Haemagglutination | Mouse IgG2a, κ |
| VS2-QX44 | Mouse Anti-KEL Recombinant Antibody (clone BRIC 107) | Haemagglutination | Mouse IgG1, κ |
| VS2-QX45 | Mouse Anti-KEL Recombinant Antibody (clone BRIC 203) | FC, IHC, IP, WB | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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