Recombinant Anti-LDLR Vesicular Antibody, EV Displayed (VS-0425-YC636)
CAT#: VS-0425-YC636
The Recombinant Anti-LDLR Vesicular Antibody, EV Displayed (VS-0425-YC636) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LDLR-expressed cells or tissues. LDLR is a low-density lipoprotein receptor impacting cholesterol synthesis, with mutations causing familial hypercholesterolemia.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human liver
Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13159/29364_A_8_3_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranou
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/25258_B_7_5.jpg
Normal Tissue
Figure 4 Stomach
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/25258_A_6_1.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/25258_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/25258_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13159/29364_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130164-LDLR
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LDLR
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse, Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Low density lipoprotein receptor
- Biological Process
- Cholesterol metabolism, Endocytosis, Host-virus interaction, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Cellular Localization
- Vesicles
- Introduction
- The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
- Alternative Names
- LDLCQ2
- Gene ID
- 3949
- UniProt ID
- P01130
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Related Diseases
Cushing Syndrome
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "LDLR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0029MZ | Recombinant Mouse Anti-Human LDLR Antibody (clone JgG-C8) | WB, FC, IF | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0040MZ | Recombinant Mouse Anti-Human Lectin-like Oxidized LDL receptor-1 (sLOX-1) Soluble form Antibody (clone C019M) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0323MZ | Chicken Anti-LDLR Polyclonal IgY | Anti-LDLR antibody produced in chicken is suitable for WBting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200. | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2033 | Hi-Affi™ Recombinant Rabbit Anti-LDLR Monoclonal Antibody (DS2033AB) | ICC, IF, WB, IP, FC, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-YC | Mouse Anti-LDLR Recombinant Antibody (clone 12G4) | ELISA, WB, IHC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-YC-S(P) | Mouse Anti-LDLR Recombinant Antibody (clone 12G4); scFv Fragment | ELISA, WB, IHC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-YC-F(E) | Mouse Anti-LDLR Recombinant Antibody (clone 12G4); Fab Fragment | ELISA, WB, IHC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0922-CN | Recombinant Rabbit Anti-LDLR Monoclonal Antibody (CBACN-345) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2011-CN | Rabbit Anti-LDLR Polyclonal Antibody (MRO-2011-CN) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0086-FY | Rabbit Anti-LDLR Recombinant Antibody (clone AFY0057) | FC, ICC, IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3975 | Anti-LDLR Immunohistochemistry Kit | IHC |
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