Recombinant Anti-LRP8 Vesicular Antibody, EV Displayed (VS-0425-YC503) (CAT#: VS-0425-YC503)
The Recombinant Anti-LRP8 Vesicular Antibody, EV Displayed (VS-0425-YC503) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LRP8-expressed cells or tissues. LRP8 is a receptor involved in neuronal migration and lipid metabolism and may be a marker in major depressive disorder. LRP8 mediates Reelin signaling.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human testis
(High expression. RNA expression: 24.0 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73031/164954_A_6_6_selected.jpg
(High expression. RNA expression: 24.0 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73031/164954_A_6_6_selected.jpg
Figure 2 IHC staining of human pancreas
(Low expression. RNA expression: 0.7 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73031/164954_A_1_3_val_selected.jpg
(Low expression. RNA expression: 0.7 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73031/164954_A_1_3_val_selected.jpg
Figure 3 Colon
(Glandular cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73031/164954_A_7_3.jpg
(Glandular cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73031/164954_A_7_3.jpg
Figure 4 Lymph node
(Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73031/164954_A_9_8.jpg
(Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73031/164954_A_9_8.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157193-LRP8
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157193-LRP8
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LRP8
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- LDL receptor related protein 8
- Biological Process
- Endocytosis, Host-virus interaction
- Molecular Function
- Receptor
- Introduction
- This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder.
- Alternative Names
- APOER2, HSZ75190, LRP-8, MCI1
- Gene ID
- 7804
- UniProt ID
- Q14114
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0660MZ | Recombinant Mouse Anti-Human LRP8 Antibody | ELISA, WB | Mouse antibody |
| HPAB-620-FY | Mouse Anti-LRP8 Recombinant Antibody (HPAB-620-FY) | FC | Mouse IgG |
| HPAB-621-FY | Human Anti-LRP8 Recombinant Antibody (HPAB-621-FY) | FC, ELISA | Human IgG1, κ |
| HPAB-622-FY | Mouse Anti-LRP8 Recombinant Antibody (HPAB-622-FY) | FC, ELISA | Mouse IgG |
| VS3-FY1652 | Rabbit Anti-LRP8 Recombinant Antibody (clone R03-1H8) | WB, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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