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LRP8
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class
Disease related genes
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Granulosa cells, Bipolar cells, Microglial cells, Excitatory neurons, Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homooligomer (PubMed:30873003). Interacts with VLDLR (PubMed:30873003). Reelin associates with two or more receptor molecules (PubMed:20223215). Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17 (By similarity). Interacts with PCSK9. Interacts with MDK; this interaction is calcium dependent (By similarity). Interacts with CLU (PubMed:24381170). (Microbial infection) Interacts with Semliki Forest virus E2-E1 heterodimer; this interaction mediates viral entry to host cell.
Molecular function
Receptor
More Types Infomation
- Rabbit Anti-LRP8 Polyclonal Antibody (MRO-1657-CN) (MRO-1657-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP
- Recombinant Mouse Anti-Human LRP8 Antibody (MOB-0660MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC
- Mouse Anti-LRP8 Recombinant Antibody; scFv Fragment (HPAB-623-FY-S(P)) (HPAB-623-FY-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: IHC
- Mouse Anti-LRP8 Recombinant Antibody (HPAB-623-FY) (HPAB-623-FY)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC
- Mouse Anti-LRP8 Recombinant Antibody (HPAB-622-FY) (HPAB-622-FY)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: FC, ELISA
- Human Anti-LRP8 Recombinant Antibody (HPAB-621-FY) (HPAB-621-FY)
-
- Species Reactivity: Human, Mouse, Cynomolgus monkey
- Type: Human IgG1, κ
- Application: FC, ELISA
- Mouse Anti-LRP8 Recombinant Antibody (HPAB-620-FY) (HPAB-620-FY)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: FC
- Mouse Anti-LRP8 Recombinant Antibody; Fab Fragment (HPAB-623-FY-F(E)) (HPAB-623-FY-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: IHC
- Mouse Anti-LRP8 Recombinant Antibody; Fab Fragment (HPAB-622-FY-F(E)) (HPAB-622-FY-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: FC, IHC
- Human Anti-LRP8 Recombinant Antibody; Fab Fragment (HPAB-621-FY-F(E)) (HPAB-621-FY-F(E))
-
- Species Reactivity: Human, Mouse, Cynomolgus monkey
- Type: Human Fab
- Application: FC, ELISA
- Mouse Anti-LRP8 Recombinant Antibody; Fab Fragment (HPAB-620-FY-F(E)) (HPAB-620-FY-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: FC
- Mouse Anti-LRP8 Recombinant Antibody; scFv Fragment (HPAB-622-FY-S(P)) (HPAB-622-FY-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: FC, IHC
- Human Anti-LRP8 Recombinant Antibody; scFv Fragment (HPAB-621-FY-S(P)) (HPAB-621-FY-S(P))
-
- Species Reactivity: Human, Mouse, Cynomolgus monkey
- Type: Human scFv
- Application: FC, ELISA
- Mouse Anti-LRP8 Recombinant Antibody; scFv Fragment (HPAB-620-FY-S(P)) (HPAB-620-FY-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: FC
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For Research Use Only. Not For Clinical Use.