Recombinant Anti-MSR1 Vesicular Antibody, EV Displayed (VS-0425-YC690)
CAT#: VS-0425-YC690
The Recombinant Anti-MSR1 Vesicular Antibody, EV Displayed (VS-0425-YC690) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MSR1-expressed cells or tissues. MSR1 enables binding activities like amyloid-beta and is involved in processes like cholesterol storage regulation and macrophage-derived foam cell differentiation, linked to conditions like Barrett's esophagus.
Gene Expression
Normal Tissue
Figure 1 Lung
Macrophages
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/272/736_A_2_4.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (BJ hTERT+, REH)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000038945-MSR1
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MSR1
- Host Animal
- Rabbit
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Macrophage scavenger receptor 1
- Biological Process
- Endocytosis
- Molecular Function
- Receptor
- Introduction
- Enables amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including endocytosis; positive regulation of cholesterol storage; and positive regulation of macrophage derived foam cell differentiation. Acts upstream of or within establishment of localization in cell and lipoprotein transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; limb; neural tube; and reproductive system. Human ortholog(s) of this gene implicated in Barrett's esophagus; arteriosclerosis; and prostate cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1).
- Alternative Names
- MRS-A, MSR, MSR-A, SR-A, SR-AI, SR-AII, Scara1, Scvr
- Gene ID
- 20288
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Datasheet
MSDS
COA
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