Recombinant Mouse Anti-PEG10 Antibody (VS4-CJ71)
CAT#: VS4-CJ71
This mouse anti-PEG10 antibody is a product that recognizes human, mouse, rabbit, porcine PEG10. The immunogen of this antibody is a purified recombinant human PEG10 protein fragment expressed in E. coli. The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunoprecipitation (1:200-1:2000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/762_H11_1_selected.jpg
Normal Tissue
Figure 2 High expression in placenta
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21324/47975_A_2_7_selected.jpg
Normal Tissue
Figure 3 Low expression in prostate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21324/47975_A_3_5_val_selected.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/137897_A_5_6.jpg
Normal Tissue
Figure 5 Placenta
Cytotrophoblasts Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/137897_A_1_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, HAP1, Hep G2, SCLC-21H)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000242265-PEG10
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Specifications
- Immunogen
- Purified recombinant human PEG10 protein fragments expressed in E. coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human, Mouse, Rabbit, Porcine PEG10
- Species Reactivity
- Human, Mouse, Rabbit, Porcine
- Applications
- ELISA, WB, IP
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.1M Tris-Glycine (150 mM NaCl), pH 7.4.
- Preservative
- 0.2% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunoprecipitation (1:200-1:2000).
Target
- Alternative Names
- EDR; HB-1; Mar2; RTL2; MEF3L; Mart2; RGAG3; SIRH1
- Gene ID
- 23089
- UniProt ID
- Q86TG7
- Long Name
- Paternally expressed 10
- Cellular Localization
- Cytoplasm, Membrane, Nucleus
- Post Translation Modifications
- Isoform 1: Undergoes proteolytic cleavage.
- Protein Refseq
- NP_001035242.1; NP_001165908.1; NP_001165909.1
- Function
- Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232).
Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232).
Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232).
Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity).
Involved at the immediate early stage of adipocyte differentiation (By similarity).
Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232).
Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509).
May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "PEG10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0970MZ | Recombinant Mouse Anti-Human PEG10 Antibody (clone 2C2D5) | ELISA, WB | Mouse antibody |
| VS3-QX867 | Mouse Anti-PEG10 Recombinant Antibody (clone 1B1C4) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-XY1244 | Mouse Anti-PEG10 Recombinant Antibody (clone 4C10A7) | ELISA, WB, IHC | Mouse IgG1 |
| VS13-YC893 | Rabbit Anti-PEG10 Recombinant Antibody (VS13-YC893) | IHC-P | Rabbit IgG |
| VS7-0425-WR593 | Mouse Anti-PEG10 Monoclonal Antibody (VS7-0425-WR593) | WB, IHC-P, IF, ICC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2660 | Hi-Affi™ Recombinant Rabbit Anti-PEG10 Monoclonal Antibody (DS2660AB) | WB, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC843 | AbPlus™ Anti-PEG10 Magnetic Beads (VS-0724-YC843) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1616 | Anti-PEG10 Immunohistochemistry Kit | IHC |
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