Recombinant Mouse Anti-PEG10 Antibody (VS4-CJ71) (CAT#: VS4-CJ71)

• Immunogen
• Purified recombinant human PEG10 protein fragments expressed in E. coli.

• Host Species
• Mouse

• Type
• Mouse IgG1

• Specificity
• Human, Mouse, Rabbit, Porcine PEG10

• Species Reactivity
• Human, Mouse, Rabbit, Porcine

• Applications
• ELISA, WB, IP

• Conjugate
• Unconjugated

• Purification
• Affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 50% Glycerol, 0.1M Tris-Glycine (150 mM NaCl), pH 7.4.

• Preservative
• 0.2% Sodium Azide

• Storage
• Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

• Application Notes
• This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunoprecipitation (1:200-1:2000).

• Alternative Names
• EDR; HB-1; Mar2; RTL2; MEF3L; Mart2; RGAG3; SIRH1

• Gene ID
• 23089

• UniProt ID
• Q86TG7

• Long Name
• Paternally expressed 10

• Cellular Localization
• Cytoplasm, Membrane, Nucleus

• Post Translation Modifications
• Isoform 1: Undergoes proteolytic cleavage.

• Protein Refseq
• NP_001035242.1; NP_001165908.1; NP_001165909.1

• Function
• Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232).
  Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232).
  Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232).
  Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity).
  Involved at the immediate early stage of adipocyte differentiation (By similarity).
  Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232).
  Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509).
  May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).

Isotype Control

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

Secondary Antibody

• 2RD-A1562-YJ
• Rabbit Anti-Mouse IgG1 Secondary antibody (Clone RM106)

• 2RD-A1460-YJ
• Goat Anti-Mouse IgG1 Secondary antibody

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