Recombinant Anti-PTGER4 Vesicular Antibody, EV Displayed (VS-0425-YC174)
CAT#: VS-0425-YC174
The Recombinant Anti-PTGER4 Vesicular Antibody, EV Displayed (VS-0425-YC174) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PTGER4-expressed cells or tissues. The PTGER4 is a receptor for prostaglandin E2 and involves pathways leading to phosphorylation of glycogen synthase kinase-3 and mediation of PGE2-induced expression.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12756/29641_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12756/29641_A_7_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12756/29641_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12756/29641_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12756/29641_A_6_6.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12756/29641_B_6_4.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12756/29641_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HDLM-2, HUVEC TERT2, LHCN-M2, RT4, THP-1, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171522-PTGER4
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PTGER4
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Prostaglandin E receptor 4
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Introduction
- The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
- Alternative Names
- EP4
- Gene ID
- 5734
- UniProt ID
- P35408
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MSDS
COA
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See other products for "PTGER4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2066-sdAb | Recombinant Anti-Human PTGER4 VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-353MZ-S(P) | Mouse Anti-PTGER4 Recombinant Antibody; scFv Fragment (TAB-353MZ-S(P)) | FC | Mouse scFv |
| TAB-354MZ-S(P) | Mouse Anti-PTGER4 Recombinant Antibody; scFv Fragment (TAB-354MZ-S(P)) | FC | Mouse scFv |
| TAB-355MZ-S(P) | Mouse Anti-PTGER4 Recombinant Antibody; scFv Fragment (TAB-355MZ-S(P)) | FC | Mouse scFv |
| TAB-354MZ-F(E) | Mouse Anti-PTGER4 Recombinant Antibody; Fab Fragment (TAB-354MZ-F(E)) | FC | Mouse Fab |
| TAB-355MZ-F(E) | Mouse Anti-PTGER4 Recombinant Antibody; Fab Fragment (TAB-355MZ-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0160 | Mouse Anti-PTGER4 Recombinant Antibody (clone Fab001) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0160-S(P) | Mouse Anti-PTGER4 Recombinant Antibody (clone Fab001); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0160-F(E) | Mouse Anti-PTGER4 Recombinant Antibody (clone Fab001); Fab Fragment | ELISA | Mouse Fab |
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