Recombinant Anti-PTPN1 Vesicular Antibody, EV Displayed (VS-0425-YC420)
CAT#: VS-0425-YC420
The Recombinant Anti-PTPN1 Vesicular Antibody, EV Displayed (VS-0425-YC420) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PTPN1-expressed cells or tissues. The PTPN1 is a protein tyrosine phosphatase involved in signaling regulation, acting on proteins like insulin and EGF receptors.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12542/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows moderate cytoplasmic positivity in germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12542/30853_A_9_8_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15217/36057_B_7_5.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15217/36057_A_7_5.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15217/36057_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196396-PTPN1/subcellular
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PTPN1
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Protein tyrosine phosphatase non-receptor type 1
- Molecular Function
- Hydrolase, Protein phosphatase
- Cellular Localization
- Endoplasmic reticulum, Cytosol
- Introduction
- The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
- Alternative Names
- PTP1B
- Gene ID
- 5770
- UniProt ID
- P18031
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2288z | Mouse Anti-PTPN1 Recombinant Antibody (clone 24A4) | WB, FC, IF, IHC | Mouse IgG2a |
| HPAB-0374-CN | Chicken Anti-PTPN1 Recombinant Antibody (HPAB-0374-CN) | WB, ELISA, IP | Chicken IgY |
| HPAB-0375-CN | Chicken Anti-PTPN1 Recombinant Antibody (HPAB-0375-CN) | WB, ELISA, IP | Chicken IgY |
| MRO-1294-CN | Recombinant Mouse Anti-PTPN1 Monoclonal Antibody (D0-C7) | WB, IF, FC | Mouse IgG1 |
| VS3-CJ733 | Rabbit Anti-PTPN1 Recombinant Antibody (VS3-CJ733) | WB, ICC, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0455MZ | Chicken Anti-PTPN1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2928 | Hi-Affi™ Recombinant Rabbit Anti-PTPN1 Monoclonal Antibody (DS2928AB) | FC, ICC, IHC-P, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0374-CN-S(P) | Chicken Anti-PTPN1 Recombinant Antibody; scFv Fragment (HPAB-0374-CN-S(P)) | WB, ELISA, IP | Chicken scFv |
| HPAB-0375-CN-S(P) | Chicken Anti-PTPN1 Recombinant Antibody; scFv Fragment (HPAB-0375-CN-S(P)) | WB, ELISA, IP | Chicken scFv |
| PSBC-544 | Chicken Anti-PTPN1 Recombinant Antibody scFv Fragment (PSBC-544) | ELISA | Chicken scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0374-CN-F(E) | Chicken Anti-PTPN1 Recombinant Antibody; Fab Fragment (HPAB-0374-CN-F(E)) | WB, ELISA, IP | Chicken Fab |
| HPAB-0375-CN-F(E) | Chicken Anti-PTPN1 Recombinant Antibody; Fab Fragment (HPAB-0375-CN-F(E)) | WB, ELISA, IP | Chicken Fab |
| PFBC-544 | Chicken Anti-PTPN1 Recombinant Antibody Fab Fragment (PFBC-544) | ELISA | Chicken Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC842 | AbPlus™ Anti-PTPN1 Magnetic Beads (VS-0724-YC842) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5858 | Anti-PTPN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5859 | Anti-Rat PTPN1 Immunohistochemistry Kit | IHC |
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