Recombinant Anti-PTPRJ Vesicular Antibody, EV Displayed (VS-0425-YC233)
CAT#: VS-0425-YC233
The Recombinant Anti-PTPRJ Vesicular Antibody, EV Displayed (VS-0425-YC233) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PTPRJ-expressed cells or tissues. The PTPRJ is a protein tyrosine phosphatase involved in signaling regulation, affecting processes like cell growth. It is present in hematopoietic lineages.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subset of germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6026/159207_A_6_8_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000149177-PTPRJ/subcellular
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PTPRJ
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Protein tyrosine phosphatase receptor type J
- Biological Process
- Angiogenesis
- Molecular Function
- Hydrolase, Protein phosphatase
- Cellular Localization
- Nucleoplasm, Cell Junctions, Nucleoli, Nuclear bodies
- Introduction
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction.
- Alternative Names
- CD148, DEP1, HPTPeta
- Gene ID
- 5795
- UniProt ID
- Q12913
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "PTPRJ"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1592CL-S(P) | Human Anti-PTPRJ Recombinant Antibody; scFv Fragment (TAB-1592CL-S(P)) | IB, IF, Inhib | Human scFv |
| TAB-1593CL-S(P) | Human Anti-PTPRJ Recombinant Antibody; scFv Fragment (TAB-1593CL-S(P)) | Inhib, ELISA | Human scFv |
| TAB-1594CL-S(P) | Human Anti-PTPRJ Recombinant Antibody; scFv Fragment (TAB-1594CL-S(P)) | Inhib | Human scFv |
| TAB-1595CL-S(P) | Human Anti-PTPRJ Recombinant Antibody; scFv Fragment (TAB-1595CL-S(P)) | Inhib | Human scFv |
| TAB-1596CL-S(P) | Human Anti-PTPRJ Recombinant Antibody; scFv Fragment (TAB-1596CL-S(P)) | Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1091MZ | Recombinant Mouse Anti-Human PTPRJ Antibody (clone B4), FITC-Conjugated | FC | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0469MZ | Chicken Anti-PTPRJ (ab1) Polyclonal IgY | WB | Chicken antibody |
| BRD-0470MZ | Chicken Anti-PTPRJ (ab2) Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2935 | Hi-Affi™ Recombinant Rabbit Anti-PTPRJ Monoclonal Antibody (DS2935AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY187 | CytoStream™ Mouse Anti-PTPRJ Recombinant Antibody (clone A3) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY43 | Mouse Anti-PTPRJ scFv-Fc Chimera (VS-0325-FY43) | ELISA | Mouse IgG1, scFv-Fc |
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