Recombinant Anti-PTPRS Vesicular Antibody, EV Displayed (VS-0425-YC364)

CAT#: VS-0425-YC364

The Recombinant Anti-PTPRS Vesicular Antibody, EV Displayed (VS-0425-YC364) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PTPRS-expressed cells or tissues. The PTPRS is a receptor-type phosphatase implicated in processes like cell interaction and axon guidance, affecting nerve repair.

Recombinant Antibody

  • Application
  • ELISA, FC, Inhib, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • PTPRS
  • Host Animal
  • Human
  • Antibody Isotype
  • IgG1 kappa
  • Species Reactivity
  • Human
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • z domain
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Binding Affinity
  • Kd = 0.85 µg/mL
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Protein tyrosine phosphatase receptor type S
  • Biological Process
  • Cell adhesion
  • Molecular Function
  • Heparin-binding, Hydrolase, Protein phosphatase, Receptor
  • Cellular Localization
  • Plasma membrane, Cytosol
  • Introduction
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair.
  • Alternative Names
  • R-PTP-S; PTPSIGMA; PTP-sigma; R-PTP-sigma
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