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PTPRS

Anti-PTPRS Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The monoclonal antibody that binds to an extracellular domain of human receptor-type protein tyrosine phosphatase σ (human PTPRS) can be used to detect, identify or isolate plasmacytoid dendritic cells (pDCs).
Protein class

Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Inhibitory neurons, Oligodendrocytes, Melanocytes, Excitatory neurons)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Cell line enhanced (AN3-CA, HaCaT)

Interaction

Binding to large heparan sulfate proteoglycan structures promotes oligomerization. Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (By similarity). Interacts (via Ig-like domains) with NTRK3 (PubMed:25385546). Interacts (via Ig-like domains) with NTRK1, but does not form detectable complexes with NTRK2 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:8524829, 9624153).

Molecular function

Heparin-binding, Hydrolase, Protein phosphatase, Receptor

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