Recombinant Anti-RAMP3 Vesicular Antibody, EV Displayed (VS-0425-YC86)
CAT#: VS-0425-YC86
The Recombinant Anti-RAMP3 Vesicular Antibody, EV Displayed (VS-0425-YC86) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to RAMP3-expressed cells or tissues. The RAMP3 is a protein required for transporting receptors involved in calcitonin-gene-related peptide receptor formation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75527/2018_G6_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122679-RAMP3
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- RAMP3
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Receptor activity modifying protein 3
- Biological Process
- Transport
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
- Gene ID
- 10268
- UniProt ID
- O60896
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Datasheet
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COA
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See other products for "RAMP3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1769CT | Recombinant Mouse anti-Human RAMP3 Monoclonal antibody (EML1061) | WB |
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