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RAMP3
Anti-RAMP3 Recombinant Antibody Products
- Mouse Anti-RAMP3 Antibody, mRNA (TAB-735CL-mRNA)
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- Species Reactivity: Human
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
Protein class
FDA approved drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Hepatic stellate cells, Endothelial cells, Adipocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (Karpas-707)
Interaction
Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.
Molecular function
Receptor
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