Recombinant Anti-SCN2B Vesicular Antibody, EV Displayed (VS-0425-YC124)

CAT#: VS-0425-YC124

The Recombinant Anti-SCN2B Vesicular Antibody, EV Displayed (VS-0425-YC124) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SCN2B-expressed cells or tissues. The SCN2B is the beta 2 subunit of the type II voltage-gated sodium channel. This encoded protein is involved in cell-cell adhesion and migration, with defects potentially causing Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome.

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • SCN2B
  • Host Animal
  • Human
  • Antibody Isotype
  • IgG1
  • Species Reactivity
  • Human
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • z domain
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Binding Affinity
  • Kd = 0.85 µg/mL
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Sodium voltage-gated channel beta subunit 2
  • Biological Process
  • Ion transport, Sodium transport, Transport
  • Molecular Function
  • Ion channel, Sodium channel, Voltage-gated channel
  • Introduction
  • The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome.
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