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SCN2B
Anti-SCN2B Recombinant Antibody Products
- Anti-Human SCN2B Recombinant Antibody (TAB-550CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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- Human Anti-SCN2B Antibody, mRNA (TAB-550CL-mRNA)
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- Species Reactivity: Human
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Excitatory neurons, Cardiomyocytes, Horizontal cells, Bipolar cells, Oligodendrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit (SCN2A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B). SCN1B and SCN3B are non-covalently associated with SCN2A. SCN2B and SCN4B are disulfide-linked to SCN2A.
Molecular function
Ion channel, Sodium channel, Voltage-gated channel
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