Recombinant Anti-SELE Vesicular Antibody, EV Displayed (VS-0425-YC600)
CAT#: VS-0425-YC600
The Recombinant Anti-SELE Vesicular Antibody, EV Displayed (VS-0425-YC600) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SELE-expressed cells or tissues. SELE is a protein in cytokine-stimulated endothelial cells, mediating leukocyte adhesion at inflammation sites. It features lectin- and EGF-like domains and participates in processes like atherosclerosis development.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2143/6009_A_7_3.jpg
Normal Tissue
Figure 2 Bone marrow
Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2143/6009_B_6_4.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HUVEC TERT2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007908-SELE
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Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SELE
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Selectin E
- Biological Process
- Cell adhesion
- Introduction
- The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
- Alternative Names
- CD62E, ELAM, ELAM1, ESEL
- Gene ID
- 6401
- UniProt ID
- P16581
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Related Signaling Pathways
TNF Signaling Pathway
Related Diseases
AGE-RAGE Signaling Pathway in Diabetic Complications
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "SELE"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1058 | Recombinant Mouse Anti-Human SELE Antibody Fab Fragment | ELISA | Fab |
| PFBW-041 | Mouse Anti-SELE Recombinant Antibody (clone 7A9); Fab Fragment | Block | Mouse Fab |
| HPAB-0236-YC-F(E) | Mouse Anti-SELE Recombinant Antibody (clone 5C7.29); Fab Fragment | FC, Block | Mouse Fab |
| HPAB-1528WJ-F(E) | Mouse Anti-SELE Recombinant Antibody; Fab Fragment (clone CY1787) | ELISA, WB | Mouse Fab |
| HPAB-1529WJ-F(E) | Human Anti-SELE Recombinant Antibody; Fab Fragment (clone CY1788) | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-041 | Mouse Anti-SELE Recombinant Antibody (clone 7A9); scFv Fragment | Block | Mouse scFv |
| HPAB-0236-YC-S(P) | Mouse Anti-SELE Recombinant Antibody (clone 5C7.29); scFv Fragment | FC, Block | Mouse scFv |
| HPAB-0237-YC-S(P) | Human Anti-SELE Recombinant Antibody (clone hu5C7.29); scFv Fragment | FC, Block | Humanized scFv |
| HPAB-1528WJ-S(P) | Mouse Anti-SELE Recombinant Antibody; scFv Fragment (clone CY1787) | ELISA, WB | Mouse scFv |
| HPAB-1529WJ-S(P) | Human Anti-SELE Recombinant Antibody; scFv Fragment (clone CY1788) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1779MZ | Recombinant Mouse Anti-Human SELE Antibody (clone 2.3C7) | ELISA, FC, IHC-Fr, IP, WB | Mouse antibody |
| HPAB-0236-YC | Mouse Anti-SELE Recombinant Antibody (clone 5C7.29) | FC, Block | Mouse IgG |
| HPAB-0006LY | Mouse Anti-SELE Recombinant Antibody (clone E1C/E1B) | WB, FC | Mouse IgG |
| HPAB-1528WJ | Mouse Anti-SELE Recombinant Antibody (clone CY1787) | ELISA, WB | Mouse IgG |
| HPAB-1529WJ | Human Anti-SELE Recombinant Antibody (clone CY1788) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1928CQ | Recombinant Mouse Anti-Sele Antibody (RME-1/CD62E) | IF, IHC, ELISA, WB, IP, BL | IgG1, κ |
| NEUT-1929CQ | Recombinant Mouse Anti-SELE Antibody (NEUT-1929CQ) | BL, FC, IP, IHC, CyTOF, ICC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY232 | AbPlus™ Anti-SELE Magnetic Beads (BBIG-E1) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6429 | Anti-SELE Immunohistochemistry Kit | IHC | |
| VS-0525-XY6430 | Anti-Mouse SELE Immunohistochemistry Kit | IHC |
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