Mouse Anti-SELE Recombinant Antibody (clone 7A9)
CAT#: PABW-041
Recombinant Mouse Antibody (7A9) is capable of binding to E-selectin (Endothelial leukocyte adhesion molecule-1). 7A9 inhibiting the attachment of neutrophils to endothelial cells. The 7A9 antigen combining site presents a groove resembling the structure of the anti-ICAM-1 antibody.
Published Data
Gene Expression
FC
Figure 1 FACS analysis of the intact 7A9 antibody and the F(ab9)2 fragment was performed in the presence (+) and absence (-) of IL-1b (1 mg/ml).
The analysis was performed on a Coulter (Epex) FACS analyzer.
Rodrıguez-Romero, A., Almog, O., Tordova, M., Randhawa, Z., & Gilliland, G. L. (1998). Primary and tertiary structures of the Fab fragment of a monoclonal anti-E-selectin 7A9 antibody that inhibits neutrophil attachment to endothelial cells. Journal of Biological Chemistry, 273(19), 11770-11775.
FuncS
Figure 2 Effect of 7A9 F(ab‘)2 on granulocyte adhesion of HL60.
The confluent HL60 in 16-mm wells were left untreated (-) or treated (+) with 1 mg/ml IL-1b for 4 h. After rinsing to remove IL-1b, cells were incubated with F(ab')2 at the indicated concentration for 30 min at 37 °C. Results are expressed as cells bound/well.
Rodrıguez-Romero, A., Almog, O., Tordova, M., Randhawa, Z., & Gilliland, G. L. (1998). Primary and tertiary structures of the Fab fragment of a monoclonal anti-E-selectin 7A9 antibody that inhibits neutrophil attachment to endothelial cells. Journal of Biological Chemistry, 273(19), 11770-11775.
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Normal Tissue
Figure 1 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2143/6009_A_7_3.jpg
Normal Tissue
Figure 2 Bone marrow
Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2143/6009_B_6_4.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HUVEC TERT2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007908-SELE
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Specifications
- Immunogen
- Human selectin E
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human SELE
- Species Reactivity
- Human
- Clone
- 7A9
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- SELE; selectin E; ELAM; ESEL; CD62E; ELAM1; LECAM2; E-selectin; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2;
- Gene ID
- 6401
- UniProt ID
- P16581
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1058 | Recombinant Mouse Anti-Human SELE Antibody Fab Fragment | ELISA | Fab |
| PFBW-041 | Mouse Anti-SELE Recombinant Antibody (clone 7A9); Fab Fragment | Block | Mouse Fab |
| HPAB-0236-YC-F(E) | Mouse Anti-SELE Recombinant Antibody (clone 5C7.29); Fab Fragment | FC, Block | Mouse Fab |
| HPAB-0237-YC-F(E) | Human Anti-SELE Recombinant Antibody (clone hu5C7.29); Fab Fragment | FC, Block | Humanized Fab |
| HPAB-1528WJ-F(E) | Mouse Anti-SELE Recombinant Antibody; Fab Fragment (clone CY1787) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-041 | Mouse Anti-SELE Recombinant Antibody (clone 7A9); scFv Fragment | Block | Mouse scFv |
| HPAB-0236-YC-S(P) | Mouse Anti-SELE Recombinant Antibody (clone 5C7.29); scFv Fragment | FC, Block | Mouse scFv |
| HPAB-0237-YC-S(P) | Human Anti-SELE Recombinant Antibody (clone hu5C7.29); scFv Fragment | FC, Block | Humanized scFv |
| HPAB-1528WJ-S(P) | Mouse Anti-SELE Recombinant Antibody; scFv Fragment (clone CY1787) | ELISA, WB | Mouse scFv |
| HPAB-1529WJ-S(P) | Human Anti-SELE Recombinant Antibody; scFv Fragment (clone CY1788) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1779MZ | Recombinant Mouse Anti-Human SELE Antibody (clone 2.3C7) | ELISA, FC, IHC-Fr, IP, WB | Mouse antibody |
| HPAB-0236-YC | Mouse Anti-SELE Recombinant Antibody (clone 5C7.29) | FC, Block | Mouse IgG |
| HPAB-0237-YC | Human Anti-SELE Recombinant Antibody (clone hu5C7.29) | FC, Block | Humanized IgG1, κ |
| HPAB-1528WJ | Mouse Anti-SELE Recombinant Antibody (clone CY1787) | ELISA, WB | Mouse IgG |
| HPAB-1529WJ | Human Anti-SELE Recombinant Antibody (clone CY1788) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1928CQ | Recombinant Mouse Anti-Sele Antibody (RME-1/CD62E) | IF, IHC, ELISA, WB, IP, BL | IgG1, κ |
| NEUT-1929CQ | Recombinant Mouse Anti-SELE Antibody (NEUT-1929CQ) | BL, FC, IP, IHC, CyTOF, ICC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY232 | AbPlus™ Anti-SELE Magnetic Beads (BBIG-E1) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC600 | Recombinant Anti-SELE Vesicular Antibody, EV Displayed (VS-0425-YC600) | Block, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6429 | Anti-SELE Immunohistochemistry Kit | IHC | |
| VS-0525-XY6430 | Anti-Mouse SELE Immunohistochemistry Kit | IHC |
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