Mouse Anti-SELE Recombinant Antibody (clone 7A9) (CAT#: PABW-041)
Recombinant Mouse Antibody (7A9) is capable of binding to E-selectin (Endothelial leukocyte adhesion molecule-1). 7A9 inhibiting the attachment of neutrophils to endothelial cells. The 7A9 antigen combining site presents a groove resembling the structure of the anti-ICAM-1 antibody.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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FC
Figure 1 FACS analysis of the intact 7A9 antibody and the F(ab9)2 fragment was performed in the presence (+) and absence (-) of IL-1b (1 mg/ml).
The analysis was performed on a Coulter (Epex) FACS analyzer.
Rodrıguez-Romero, A., Almog, O., Tordova, M., Randhawa, Z., & Gilliland, G. L. (1998). Primary and tertiary structures of the Fab fragment of a monoclonal anti-E-selectin 7A9 antibody that inhibits neutrophil attachment to endothelial cells. Journal of Biological Chemistry, 273(19), 11770-11775.
FuncS
Figure 2 Effect of 7A9 F(ab‘)2 on granulocyte adhesion of HL60.
The confluent HL60 in 16-mm wells were left untreated (-) or treated (+) with 1 mg/ml IL-1b for 4 h. After rinsing to remove IL-1b, cells were incubated with F(ab')2 at the indicated concentration for 30 min at 37 °C. Results are expressed as cells bound/well.
Rodrıguez-Romero, A., Almog, O., Tordova, M., Randhawa, Z., & Gilliland, G. L. (1998). Primary and tertiary structures of the Fab fragment of a monoclonal anti-E-selectin 7A9 antibody that inhibits neutrophil attachment to endothelial cells. Journal of Biological Chemistry, 273(19), 11770-11775.
Specifications
- Immunogen
- Human selectin E
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human SELE
- Species Reactivity
- Human
- Clone
- 7A9
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- SELE; selectin E; ELAM; ESEL; CD62E; ELAM1; LECAM2; E-selectin; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2;
- Gene ID
- 6401
- UniProt ID
- P16581
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1058 | Recombinant Mouse Anti-Human SELE Antibody Fab Fragment | ELISA | Fab |
| HPAB-0236-YC-F(E) | Mouse Anti-SELE Recombinant Antibody (clone 5C7.29); Fab Fragment | FC, Block | Mouse Fab |
| HPAB-0237-YC-F(E) | Human Anti-SELE Recombinant Antibody (clone hu5C7.29); Fab Fragment | FC, Block | Humanized Fab |
| HPAB-1528WJ-F(E) | Mouse Anti-SELE Recombinant Antibody; Fab Fragment (clone CY1787) | ELISA, WB | Mouse Fab |
| HPAB-1529WJ-F(E) | Human Anti-SELE Recombinant Antibody; Fab Fragment (clone CY1788) | ELISA, WB | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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