Recombinant Anti-SIGLEC1 Vesicular Antibody, EV Displayed (VS-0425-YC512)
CAT#: VS-0425-YC512
The Recombinant Anti-SIGLEC1 Vesicular Antibody, EV Displayed (VS-0425-YC512) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SIGLEC1-expressed cells or tissues. SIGLEC1 is an adhesion molecule in macrophages, mediating cell interactions in a sialic acid-dependent manner. SIGLEC1 includes both membrane-bound and soluble isoforms.
Gene Expression
Normal Tissue
Figure 1 Lung
Macrophages
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53457/128072_A_1_4.jpg
Normal Tissue
Figure 2 Testis
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53457/128072_A_6_6.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000088827-SIGLEC1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SIGLEC1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Sialic acid binding Ig like lectin 1
- Biological Process
- Cell adhesion, Endocytosis
- Introduction
- This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined.
- Alternative Names
- CD169, dJ1009E24.1, FLJ00051, FLJ00055, FLJ00073, FLJ32150, sialoadhesin, SIGLEC-1, SN
- Gene ID
- 6614
- UniProt ID
- Q9BZZ2
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Datasheet
MSDS
COA
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See other products for "Siglec1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-106 | Recombinant Rat Anti-Mouse Siglec1 Antibody, clone 3D6.112 | FC, IHC, ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1373CT | Recombinant Mouse anti-Human SIGLEC1 Monoclonal antibody (8-340) | FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1762LY-S(P) | Human Anti-SIGLEC1 Recombinant Antibody (clone CBL038); scfv Fragment | FC, ELISA, Inhib | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1762LY | Human Anti-SIGLEC1 Recombinant Antibody (clone CBL038) | FC, ELISA, Inhib | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1762LY-F(E) | Human Anti-SIGLEC1 Recombinant Antibody (clone CBL038); Fab Fragment | FC, ELISA, Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1630CQ | Rabbit Anti-SIGLEC1 Recombinant Antibody (clone SER-4) | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6576 | Anti-Mouse SIGLEC1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6578 | Anti-Rat SIGLEC1 Immunohistochemistry Kit | IHC |
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