Recombinant Mouse Anti-SLC2A1 Antibody (clone 1G5-8F2-7D10) (CAT#: VS3-FY1346)

• Immunogen
• Synthetic peptide derived from human GLUT-1.

• Host Species
• Mouse

• Type
• Mouse IgG3

• Specificity
• Human SLC2A1

• Species Reactivity
• Human

• Clone
• 1G5-8F2-7D10

• Applications
• Immunohistochemistry-Paraffin

• Conjugate
• Unconjugated

• Purification
• Affinity Chromatography

• Purity
• >95% as determined by SDS-PAGE

• Buffer
• PBS, pH 7.3, 50% glycerol, 0.5% BSA

• Preservative
• 0.02% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunohistochemistry-Paraffin: 1/100-1/500

• Alternative Names
• Solute Carrier Family 2 Member 1; Choreoathetosis/Spasticity, Episodic (Paroxysmal Choreoathetosis/Spasticity); Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1; Human T-Cell Leukemia Virus (I And II) Receptor; Glucose Transporter Type 1, Erythrocyte/Brain; HepG2 Glucose Transporter; GLUT-1; GLUT1; Solute Carrier Family 2, Facilitated Glucose Transporter Member 1; Receptor For HTLV-1 And HTLV-2; GLUT1DS

• Gene ID
• 6513

• UniProt ID
• P11166

• Sequence Similarities
• Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

• Cellular Localization
• Cell membrane, Membrane

• Post Translation Modifications
• Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.

• Protein Refseq
• NP_006507.2

• Function
• Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690).
  Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892).
  Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690).
  In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).

Secondary Antibody

• 2ND-050CQ
• Goat Anti-Mouse IgG3 Antibody, R-PE

• 2RD-A1470-YJ
• Goat Anti-Mouse IgG3 Secondary antibody

• 2RD-A1569-YJ
• Rabbit Anti-Mouse IgG3 Secondary antibody (Clone RM218)

Isotype Control

• MOB-205CQ
• Mouse IgG3, kappa Isotype Control Antibody

Reconstitution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS