Recombinant Mouse Anti-SST Antibody (clone 2G2-1B5-10A3)
CAT#: VS3-FY1394
This product is a recombinant mouse antibody that recognizes SST. This antibody has been reported for use in Immunohistochemistry-Paraffin. The clone 2G2-1B5-10A3 is specific for human SST. The antigen is synthetic peptide derived from human somatostatin.
Gene Expression
Tested Data
Normal Tissue
Figure 1 Duodenum
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19472/164703_A_8_2_val_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuropil Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19472/164703_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes -
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19472/164703_A_7_3.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (EFO-21, U-2 OS, U-251 MG, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157005-SST
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IHC-P
Figure 1. Recombinant Mouse Anti-SST Antibody (clone 2G2-1B5-10A3) in IHC-P.
Immunohistochemical analysis of paraffin-embedded pancreas using somatostatin antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
IHC-P
Figure 2. Recombinant Mouse Anti-SST Antibody (clone 2G2-1B5-10A3) in IHC-P.
Immunohistochemical analysis of paraffin-embedded pancreas using somatostatin antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
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Specifications
- Immunogen
- Synthetic peptide derived from human somatostatin.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human SST
- Species Reactivity
- Human
- Clone
- 2G2-1B5-10A3
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry-Paraffin: 1/100-1/500
Target
- Alternative Names
- Somatostatin; Growth Hormone Release-Inhibiting Factor; Prepro-Somatostatin; Somatostatin-14; Somatostatin-28; SMST
- Gene ID
- 6750
- UniProt ID
- P61278
- Sequence Similarities
- Belongs to the somatostatin family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.
- Protein Refseq
- NP_001039.1
- Function
- Somatostatin-14:
Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.
Neuronostatin:
May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity).
This effect may be mediated by binding to GPR107 and PKA activation (By similarity).
May regulate cardiac contractile function (By similarity).
May compromise cardiomyocyte viability (By similarity).
In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity).
May also have anxiolytic and anorexigenic effects (By similarity).
May play a role in arterial pressure regulation (By similarity).
May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "SST"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3413 | Hi-Affi™ Recombinant Rabbit Anti-SST Monoclonal Antibody (DS3413AB) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0248F | Mouse Anti-SST Recombinant Antibody (MOB-0248F) | IHC-P, IF | Mouse IgG |
| MOB-0249F | Mouse Anti-SST Recombinant Antibody (MOB-0249F) | IHC-P, IF | Mouse IgG |
| VS3-QX1055 | Mouse Anti-SST Recombinant Antibody (clone 7G5) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-CJ1075 | Mouse Anti-SST Recombinant Antibody (clone ABT-SST) | IHC-P | Mouse IgG2b, κ |
| VS3-XY3514 | Rabbit Anti-SST Recombinant Antibody (clone R28-4V-8) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6921 | Anti-SST Immunohistochemistry Kit | IHC | |
| VS-0525-XY6922 | Anti-Mouse SST Immunohistochemistry Kit | IHC | |
| VS-0525-XY6923 | Anti-Rat SST Immunohistochemistry Kit | IHC |
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