Recombinant Anti-TENM2 Vesicular Antibody, EV Displayed (VS-0425-YC582)
CAT#: VS-0425-YC582
The Recombinant Anti-TENM2 Vesicular Antibody, EV Displayed (VS-0425-YC582) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TENM2-expressed cells or tissues. TENM2 enables cell adhesion and signaling receptor binding, involved in retrograde trans-synaptic signaling through cell junctions and the plasma membrane.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoli.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68691/1402_D5_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human adrenal gland
Immunohistochemical staining of human adrenal gland shows strong cytoplasmic and nuclear positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38018/ihc_selected.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38420/79314_A_9_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38420/79314_B_7_5.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38420/79314_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38420/79314_A_4_6.jpg
Normal Tissue
Figure 7 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38420/79314_B_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (fHDF/TERT166, HBEC3-KT, HDLM-2, U-138 MG, U-2 OS, U-251 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145934-TENM2
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TENM2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Teneurin transmembrane protein 2
- Biological Process
- Cell adhesion, Transcription, Transcription regulation
- Molecular Function
- Repressor
- Cellular Localization
- Nucleoli
- Introduction
- Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in retrograde trans-synaptic signaling by trans-synaptic protein complex. Located in cell-cell junction and plasma membrane.
- Alternative Names
- KIAA1127, ODZ2, Ten-M2, TEN2
- Gene ID
- 57451
- UniProt ID
- Q9NT68
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0306CQ | Human Anti-TENM2 Recombinant Antibody (HPAB-0306CQ) | Inhib, WB, IHC, FuncS | Human IgG2, κ |
| HPAB-1804-FY | Human Anti-TENM2 Recombinant Antibody (HPAB-1804-FY) | ELISA | Human IgG |
| HPAB-1805-FY | Human Anti-TENM2 Recombinant Antibody (HPAB-1805-FY) | ELISA | Human IgG |
| HPAB-1806-FY | Human Anti-TENM2 Recombinant Antibody (HPAB-1806-FY) | FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0306CQ-F(E) | Human Anti-TENM2 Recombinant Antibody; Fab Fragment (HPAB-0306CQ-F(E)) | ELISA, WB, IHC, FC | Human Fab |
| HPAB-1804-FY-S(P) | Human Anti-TENM2 Recombinant Antibody; scFv Fragment (HPAB-1804-FY-S(P)) | ELISA | Human scFv |
| HPAB-1805-FY-S(P) | Human Anti-TENM2 Recombinant Antibody; scFv Fragment (HPAB-1805-FY-S(P)) | ELISA | Human scFv |
| HPAB-1806-FY-S(P) | Human Anti-TENM2 Recombinant Antibody; scFv Fragment (HPAB-1806-FY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0306CQ-S(P) | Human Anti-TENM2 Recombinant Antibody; scFv Fragment (HPAB-0306CQ-S(P)) | ELISA, WB, IHC, FC | Human scFv |
| HPAB-1804-FY-F(E) | Human Anti-TENM2 Recombinant Antibody; Fab Fragment (HPAB-1804-FY-F(E)) | ELISA | Human Fab |
| HPAB-1805-FY-F(E) | Human Anti-TENM2 Recombinant Antibody; Fab Fragment (HPAB-1805-FY-F(E)) | ELISA | Human Fab |
| HPAB-1806-FY-F(E) | Human Anti-TENM2 Recombinant Antibody; Fab Fragment (HPAB-1806-FY-F(E)) | ELISA | Human Fab |
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