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TENM2

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For Research Use Only. Not For Clinical Use.


Background

Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in retrograde trans-synaptic signaling by trans-synaptic protein complex. Located in cell-cell junction and plasma membrane.
Protein class

Transporters

Predicted location

Membrane

Single cell type specificity

Group enriched (Inhibitory neurons, Excitatory neurons, Astrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (fHDF/TERT166, HBEC3-KT, HDLM-2, U-138 MG, U-2 OS, U-251 MG)

Interaction

Homodimer; disulfide-linked (Probable). Heterodimer with either TENM1 or TENM3. May also form heterodimer with TENM4 (By similarity). Isoform 2 (C-terminal globular domain) interacts with ADGRL1 isoform 2.

Molecular function

Repressor

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