Recombinant Anti-TERT Vesicular Antibody, EV Displayed (VS-0425-YC111)
CAT#: VS-0425-YC111
The Recombinant Anti-TERT Vesicular Antibody, EV Displayed (VS-0425-YC111) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TERT-expressed cells or tissues. The TERT is telomerase, which maintains telomere ends by adding TTAGGG repeats and consists of a reverse transcriptase protein and RNA template. Normally repressed postnatally, telomerase expression is linked to cellular senescence and its deregulation may lead to oncogenesis.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line LHCN-M2
Immunofluorescent staining of human cell line LHCN-M2 shows localization to nucleoplasm & nuclear speckles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/1782_B1_17_cr596b5f3cb51d0_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows no positivity in hepatocytes and bile duct cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_9_4_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_7_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164362-TERT/subcellular
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TERT
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Telomerase reverse transcriptase
- Molecular Function
- DNA-binding, Nucleotidyltransferase, Ribonucleoprotein, RNA-directed DNA polymerase, Transferase
- Cellular Localization
- Nucleoplasm, Nuclear speckles, Cytosol
- Introduction
- Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
- Alternative Names
- EST2, hEST2, TCS1, TP2, TRT
- Gene ID
- 7015
- UniProt ID
- O14746
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "TERT"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-962-F(E) | Recombinant Anti-human TERT Antibody Fab Fragment | ELISA, RIA, FuncS | Fab |
| MHH-962-F(E) | Recombinant Human Anti-human TERT Antibody Fab Fragment | WB, IHC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-962-S(P) | Recombinant Anti-human TERT Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-962-S(P) | Recombinant Human Anti-human TERT Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-050 | Recombinant Anti-human TERT VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B046(A) | Recombinant Anti-human TERT Intrabody [(D-Arg)9] | PCA, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B046(G) | Recombinant Anti-human TERT Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
| IAB-B046(T) | Recombinant Anti-human TERT Intrabody [Tat] | WB, ICC, Neut, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2004CT | Recombinant Mouse anti-Human TERT Monoclonal antibody (3D5) | FC, ICC, IF, IHC-P, IP, WB | |
| MRO-1480-CN | Rabbit Anti-TERT Recombinant Antibody (clone JF0586) | WB, FC | Rabbit IgG |
| VS3-WK148 | Mouse Anti-TERT Recombinant Antibody (clone G9-H2) | WB, ELISA | Mouse IgG1 |
| VS7-0425-WR962 | Mouse Anti-TERT Recombinant Antibody (clone 3H2C12) | IHC, FC | Mouse IgG1 |
| VS7-0425-WR963 | Mouse Anti-TERT Recombinant Antibody (clone 3H2G9) | IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0581MZ | Chicken Anti-TERT Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3533 | Rabbit Anti-TERT Recombinant Antibody (clone DS3533AB) | FC, ICC, IF, IHC-Fr, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7173 | Anti-TERT Immunohistochemistry Kit | IHC |
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