Anti-TERT Intrabody [(D-Arg)9] (IAB-B046(A))
Recombinant anti-TERT intrabody linked to (D-Arg)9 works within cells and specifically reacts with human TERT, expressed in CHO cells. The intrabody can directed against hTERT to attenuate the immortalization of human uterine cervix and hepatoma cells.
Specifications
- Immunogen
- human telomerase reverse transcriptase
- Host
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Protein fragment complementation; Neutralization; Functional studies
Target
- Alternative Names
- TERT; telomerase reverse transcriptase; TP2; TRT; CMM9; EST2; TCS1; hTRT
- Entrez Gene ID
- 7015
- UniProt ID
- O14746
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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