Recombinant Anti-human TERT Intrabody [(D-Arg)9] (CAT#: IAB-B046(A))
Recombinant anti-TERT intrabody linked to (D-Arg)9 works within cells and specifically reacts with human TERT, expressed in CHO cells. The intrabody can directed against hTERT to attenuate the immortalization of human uterine cervix and hepatoma cells.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line LHCN-M2
(Immunofluorescent staining of human cell line LHCN-M2 shows localization to nucleoplasm & nuclear speckles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/1782_B1_17_cr596b5f3cb51d0_selected.jpg
(Immunofluorescent staining of human cell line LHCN-M2 shows localization to nucleoplasm & nuclear speckles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/1782_B1_17_cr596b5f3cb51d0_selected.jpg
Figure 2 IHC staining of human liver
(Immunohistochemical staining of human liver shows no positivity in hepatocytes and bile duct cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_9_4_selected.jpg
(Immunohistochemical staining of human liver shows no positivity in hepatocytes and bile duct cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_9_4_selected.jpg
Figure 3 Kidney
(Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_7_5.jpg
(Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_7_5.jpg
Figure 4 RNA cell line category: Cell line enhanced.
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164362-TERT/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164362-TERT/subcellular
Specifications
- Immunogen
- human telomerase reverse transcriptase
- Host Species
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Protein fragment complementation; Neutralization; Functional studies
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
- Alternative Names
- TERT; telomerase reverse transcriptase; TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1; telomerase catalytic subunit; telomerase-associated protein 2
- Gene ID
- 7015
- UniProt ID
- O14746
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-962 | Recombinant Anti-human TERT Antibody | WB, IHC, FuncS | IgG |
| MHH-962 | Recombinant Human Anti-human TERT Antibody | WB, Neut, FuncS | IgG |
| MOB-2004CT | Recombinant Mouse anti-Human TERT Monoclonal antibody (3D5) | FC, ICC/IF, IHC-P, IP, WB | |
| MRO-1480-CN | Rabbit Anti-TERT Recombinant Antibody (clone JF0586) | WB, FC | Rabbit IgG |
| VS3-XY1495 | Mouse Anti-TERT Recombinant Antibody (clone 7E4B8) | ELISA, WB, IHC, FC | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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