Recombinant Anti-human TERT Intrabody [(D-Arg)9]
CAT#: IAB-B046(A)
Recombinant anti-TERT intrabody linked to (D-Arg)9 works within cells and specifically reacts with human TERT, expressed in CHO cells. The intrabody can directed against hTERT to attenuate the immortalization of human uterine cervix and hepatoma cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line LHCN-M2
Immunofluorescent staining of human cell line LHCN-M2 shows localization to nucleoplasm & nuclear speckles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/1782_B1_17_cr596b5f3cb51d0_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows no positivity in hepatocytes and bile duct cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_9_4_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_7_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164362-TERT/subcellular
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Specifications
- Immunogen
- human telomerase reverse transcriptase
- Host Species
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Protein fragment complementation; Neutralization; Functional studies
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TERT"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-962-F(E) | Recombinant Anti-human TERT Antibody Fab Fragment | ELISA, RIA, FuncS | Fab |
| MHH-962-F(E) | Recombinant Human Anti-human TERT Antibody Fab Fragment | WB, IHC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-962-S(P) | Recombinant Anti-human TERT Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-962-S(P) | Recombinant Human Anti-human TERT Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-050 | Recombinant Anti-human TERT VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B046(G) | Recombinant Anti-human TERT Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
| IAB-B046(T) | Recombinant Anti-human TERT Intrabody [Tat] | WB, ICC, Neut, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0581MZ | Chicken Anti-TERT Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3533 | Rabbit Anti-TERT Recombinant Antibody (clone DS3533AB) | FC, ICC, IF, IHC-Fr, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1480-CN | Rabbit Anti-TERT Recombinant Antibody (clone JF0586) | WB, FC | Rabbit IgG |
| VS3-WK148 | Mouse Anti-TERT Recombinant Antibody (clone G9-H2) | WB, ELISA | Mouse IgG1 |
| VS3-WK1253 | Mouse Anti-TERT Recombinant Antibody (VS3-WK1253) | ELISA, WB | Mouse IgG1 |
| VS7-0425-WR962 | Mouse Anti-TERT Recombinant Antibody (clone 3H2C12) | IHC, FC | Mouse IgG1 |
| VS7-0425-WR963 | Mouse Anti-TERT Recombinant Antibody (clone 3H2G9) | IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC111 | Recombinant Anti-TERT Vesicular Antibody, EV Displayed (VS-0425-YC111) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7173 | Anti-TERT Immunohistochemistry Kit | IHC |
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