Recombinant Anti-TM4SF20 Vesicular Antibody, EV Displayed (VS-0425-YC492)
CAT#: VS-0425-YC492
The Recombinant Anti-TM4SF20 Vesicular Antibody, EV Displayed (VS-0425-YC492) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TM4SF20-expressed cells or tissues. TM4SF20 is part of the four-transmembrane L6 superfamily and is involved in cell processes and expressed in various brain structures. Deletion of TM4SF20 in humans is associated with language impairment.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to plasma membrane & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65531/1339_H10_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic and membranous glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51838/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63184/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to plasma membrane & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65531/1304_C2_4_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51838/153497_B_7_5.jpg
Normal Tissue
Figure 6 Small intestine
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51838/153497_A_4_2.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51838/153497_A_5_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (A549, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168955-TM4SF20
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TM4SF20
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Transmembrane 4 L six family member 20
- Cellular Localization
- Plasma membrane, Focal adhesion sites
- Introduction
- The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5. [provided by RefSeq, Jul 2016]
- Alternative Names
- FLJ22800, TCCE518
- Gene ID
- 79853
- UniProt ID
- Q53R12
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2418-VHH | Recombinant Anti-Human TM4SF20 VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP820-YC | Mouse Anti-TM4SF20 Recombinant Antibody (HPAB-AP820-YC) | FC, FuncS | Mouse IgG |
| HPAB-AP821-YC | Mouse Anti-TM4SF20 Recombinant Antibody (HPAB-AP821-YC) | FC | Mouse IgG |
| HPAB-AP822-YC | Mouse Anti-TM4SF20 Recombinant Antibody (HPAB-AP822-YC) | FC, FuncS | Mouse IgG |
| HPAB-AP823-YC | Mouse Anti-TM4SF20 Recombinant Antibody (HPAB-AP823-YC) | FC, FuncS | Mouse IgG |
| HPAB-AP824-YC | Mouse Anti-TM4SF20 Recombinant Antibody (HPAB-AP824-YC) | FC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP820-YC-S(P) | Mouse Anti-TM4SF20 Recombinant Antibody; scFv Fragment (HPAB-AP820-YC-S(P)) | FC, WB, ADCC | Mouse scFv |
| HPAB-AP821-YC-S(P) | Mouse Anti-TM4SF20 Recombinant Antibody; scFv Fragment (HPAB-AP821-YC-S(P)) | FC, WB, ADCC | Mouse scFv |
| HPAB-AP822-YC-S(P) | Mouse Anti-TM4SF20 Recombinant Antibody; scFv Fragment (HPAB-AP822-YC-S(P)) | FC, WB, ADCC | Mouse scFv |
| HPAB-AP823-YC-S(P) | Mouse Anti-TM4SF20 Recombinant Antibody; scFv Fragment (HPAB-AP823-YC-S(P)) | FC, WB, ADCC | Mouse scFv |
| HPAB-AP824-YC-S(P) | Mouse Anti-TM4SF20 Recombinant Antibody; scFv Fragment (HPAB-AP824-YC-S(P)) | FC, WB, ADCC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP820-YC-F(E) | Mouse Anti-TM4SF20 Recombinant Antibody; Fab Fragment (HPAB-AP820-YC-F(E)) | FC, WB, ADCC | Mouse Fab |
| HPAB-AP821-YC-F(E) | Mouse Anti-TM4SF20 Recombinant Antibody; Fab Fragment (HPAB-AP821-YC-F(E)) | FC, WB, ADCC | Mouse Fab |
| HPAB-AP822-YC-F(E) | Mouse Anti-TM4SF20 Recombinant Antibody; Fab Fragment (HPAB-AP822-YC-F(E)) | FC, WB, ADCC | Mouse Fab |
| HPAB-AP823-YC-F(E) | Mouse Anti-TM4SF20 Recombinant Antibody; Fab Fragment (HPAB-AP823-YC-F(E)) | FC, WB, ADCC | Mouse Fab |
| HPAB-AP824-YC-F(E) | Mouse Anti-TM4SF20 Recombinant Antibody; Fab Fragment (HPAB-AP824-YC-F(E)) | FC, WB, ADCC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY104 | Human Anti-TM4SF20 scFv-Fc Chimera (VS-0325-FY104) | IA | Human IgG1, scFv-Fc |
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