Human Anti-TM4SF20 scFv-Fc Chimera (VS-0325-FY104) (CAT#: VS-0325-FY104)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human TM4SF20

• Species Reactivity
• Human

• Applications
• Immunoassay

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Transmembrane 4 L Six Family Member 20; Transmembrane 4 L6 Family Member 20; TCCE518; PRO994; SLI5

• Gene ID
• 79853

• UniProt ID
• Q53R12

• Long Name
• Transmembrane 4 L Six Family Member 20

• Sequence Similarities
• Belongs to the L6 tetraspanin family.

• Cellular Localization
• Membrane; Endoplasmic reticulum membrane

• Post Translation Modifications
• Glycosylated at Asn-132, Asn-148 and Asn-163 in presence of ceramide which inverts the orientation of TM4SF20 in membranes exposing these residues to the endoplasmic reticulum lumen.
  Cleaved by signal peptidase at Ser-14 but the peptide does not act as a signal peptide.
  Cleavage is inhibited by ceramide which inverts the orientation of TM4SF20 in membranes exposing the N-terminus to the cytosol and not to the endoplasmic reticulum lumen.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• XP_011510178.1; XP_054199970.1; XP_054199971.1; NP_079071.2

• Function
• TM4SF20 (Tetraspanin membrane 4 superfamily member 20) is a membrane protein with functions in cell adhesion and signaling, however the specific functions are still being discovered, and studied. It's role in certain cancers is being investigated.

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

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