Recombinant Anti-TNFRSF1A Vesicular Antibody, EV Displayed (VS-0425-YC265)
CAT#: VS-0425-YC265
The Recombinant Anti-TNFRSF1A Vesicular Antibody, EV Displayed (VS-0425-YC265) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TNFRSF1A-expressed cells or tissues. The TNFRSF1A is a receptor involved in cell survival and inflammatory processes, affected by mutations causing TRAPS and linked to multiple sclerosis.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_9_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_6_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10309/25571_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000067182-TNFRSF1A
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TNFRSF1A
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human, Rhesus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- TNF receptor superfamily member 1A
- Biological Process
- Apoptosis, Host-virus interaction
- Molecular Function
- Receptor
- Introduction
- This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
- Alternative Names
- CD120a, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR60
- Gene ID
- 7132
- UniProt ID
- P19438
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Datasheet
MSDS
COA
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-107CQ-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (TAB-107CQ-S(P)) | ELISA, FC, Neut | Humanized scFv |
| TAB-107CQ-F(E) | Human Anti-TNFRSF1A Recombinant Antibody; Fab Fragment (TAB-107CQ-F(E)) | ELISA, FC, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| NEUT-2145CQ | Hamster Anti-Tnfrsf1a Recombinant Antibody (clone CBL178) | FC, ELISA, WB, IP, Neut | Hamster IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3613 | Rabbit Anti-TNFRSF1A Recombinant Antibody (clone DS3613AB) | WB, FC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1695LY-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (HPAB-1695LY-S(P)) | ELISA, FC, Inhib | Human scFv |
| HPAB-1696LY-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (HPAB-1696LY-S(P)) | ELISA, FC, Inhib | Human scFv |
| HPAB-N0275-YC-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (HPAB-N0275-YC-S(P)) | ELISA | Human scFv |
| HPAB-1441-FY-S(P) | Human Anti-TNFRSF1A Recombinant Antibody; scFv Fragment (HPAB-1441-FY-S(P)) | ELISA, Inhib, IF, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1695LY-F(E) | Human Anti-TNFRSF1A Recombinant Antibody; Fab Fragment (HPAB-1695LY-F(E)) | ELISA, FC, Inhib | Humanized Fab |
| HPAB-1696LY-F(E) | Human Anti-TNFRSF1A Recombinant Antibody; Fab Fragment (HPAB-1696LY-F(E)) | ELISA, FC, Inhib | Humanized Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-J0306-YC | Recombinant Human Anti-TNFRSF1A Single Domain Antibody (HPAB-J0306-YC) | ELISA, Inhib | Human VHH |
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| HPAB-J0308-YC | Recombinant Human Anti-TNFRSF1A Single Domain Antibody (HPAB-J0308-YC) | ELISA, Inhib | Human VHH |
| HPAB-J0309-YC | Recombinant Human Anti-TNFRSF1A Single Domain Antibody (HPAB-J0309-YC) | ELISA, Inhib | Human VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7380 | Anti-TNFRSF1A Immunohistochemistry Kit | IHC |
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