Recombinant Anti-UNC5B Vesicular Antibody, EV Displayed (VS-0425-YC652) (CAT#: VS-0425-YC652)

• Application
• Block, ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• UNC5B

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Mouse

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Unc-5 netrin receptor B

• Biological Process
• Angiogenesis, Apoptosis

• Molecular Function
• Developmental protein, Receptor

• Introduction
• This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.

• Alternative Names
• p53RDL1, UNC5H2

• Gene ID
• 219699

• UniProt ID
• Q8IZJ1

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