Recombinant Anti-UNC5B Vesicular Antibody, EV Displayed (VS-0425-YC652)
CAT#: VS-0425-YC652
The Recombinant Anti-UNC5B Vesicular Antibody, EV Displayed (VS-0425-YC652) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to UNC5B-expressed cells or tissues. UNC5B is a member of the netrin family of receptors involved in the repulsive effects of netrin-1 and vascular signaling. Classified as a dependence receptor, it plays a role in pro- and anti-apoptotic processes that influence embryogenesis and cancer progression.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_4_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_B_8_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Leydig cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_6_6.jpg
Normal Tissue
Figure 5 Seminal vesicle
Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_9_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HaCaT, HHSteC, hTCEpi, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107731-UNC5B
❮
❯
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- UNC5B
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Unc-5 netrin receptor B
- Biological Process
- Angiogenesis, Apoptosis
- Molecular Function
- Developmental protein, Receptor
- Introduction
- This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
- Alternative Names
- p53RDL1, UNC5H2
- Gene ID
- 219699
- UniProt ID
- Q8IZJ1
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "UNC5B"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-229CQ | Anti-Human UNC5B Recombinant Antibody (YW83.21) | ELISA, FC, WB | Human antibody |
| TAB-229CQ-S(P) | Anti-Human UNC5B Recombinant Antibody scFv Fragment (YW83.21) | ELISA, FC, WB | Human antibody |
| TAB-229CQ-F(E) | Anti-Human UNC5B Recombinant Antibody Fab Fragment (YW83.21) | ELISA, FC, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1239MZ | Recombinant Mouse Anti-Human UNC5B Antibody (clone Hvjep-2) | FC, ICC, IF | Mouse antibody |
| HPAB-0058CQ | Human Anti-UNC5B Recombinant Antibody (clone YW88.82) | WB, FC, Block | Human IgG1, κ |
| HPAB-AP840-YC | Human Anti-UNC5B Recombinant Antibody (clone AP014/YC) | ELISA, FC, WB | Human IgG |
| HPAB-AP841-YC | Human Anti-UNC5B Recombinant Antibody (clone AP015/YC) | ELISA, FC, WB | Human IgG |
| HPAB-AP842-YC | Human Anti-UNC5B Recombinant Antibody (clone AP016/YC) | ELISA, FC, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0058CQ-S(P) | Human Anti-UNC5B Recombinant Antibody (clone YW88.82); scFv Fragment | WB, FC, Block | Human scFv |
| HPAB-0059CQ-S(P) | Human Anti-UNC5B Recombinant Antibody (clone YW83.7); scFv Fragment | WB, FC | Human scFv |
| HPAB-AP840-YC-S(P) | Human Anti-UNC5B Recombinant Antibody (clone AP014/YC); scFv Fragment | ELISA, FC, WB | Human scFv |
| HPAB-AP841-YC-S(P) | Human Anti-UNC5B Recombinant Antibody (clone AP015/YC); scFv Fragment | ELISA, FC, WB | Human scFv |
| HPAB-AP842-YC-S(P) | Human Anti-UNC5B Recombinant Antibody (clone AP016/YC); scFv Fragment | ELISA, FC, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0058CQ-F(E) | Human Anti-UNC5B Recombinant Antibody (clone YW88.82); Fab Fragment | WB, FC, Block | Human Fab |
| HPAB-0059CQ-F(E) | Human Anti-UNC5B Recombinant Antibody (clone YW83.7); Fab Fragment | WB, FC | Human Fab |
| HPAB-0060CQ-F(E) | Human Anti-UNC5B Recombinant Antibody (clone YW83.4); Fab Fragment | WB, FC | Human Fab |
| HPAB-0061CQ-F(E) | Human Anti-UNC5B Recombinant Antibody (clone YW88.7); Fab Fragment | WB, FC, Block | Human Fab |
| HPAB-AP840-YC-F(E) | Human Anti-UNC5B Recombinant Antibody (clone AP014/YC); Fab Fragment | ELISA, FC, WB | Human Fab |
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