What research applications can the Recombinant Anti-Human UNC5B Antibody be used for?

The Recombinant Anti-Human UNC5B Antibody can be utilized in various research applications such as flow cytometry (FC), immunocytochemistry/immunofluorescence (ICC/IF), and other cell signaling studies. It is particularly valuable in neuroscience and cancer biomarker research, providing insights into cell signalling pathways and protein interactions, which are critical for understanding tumourigenesis and neuronal cell behavior.

How can the UNC5B antibody help in studying cancer's underlying mechanisms?

UNC5B is a receptor involved in cell survival and apoptosis, playing a significant role in cancer biology. Understanding how UNC5B interactions trigger apoptosis pathways can be crucial for developing cancer treatments. This antibody helps researchers identify the expression patterns of UNC5B in various cell types, providing a detailed understanding of its role in cancer progression and metastasis.

What specific targets does the Recombinant Anti-Human UNC5B Antibody bind to?

This antibody targets the human UNC5B receptor, which is part of the netrin receptor family critical in neural development and axon guidance. Such specificity makes it instrumental in studying pathways involving cellular adhesion and migration, providing clarity on how these processes might go awry in diseases.

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UNC5B
Recombinant Mouse Anti-Human UNC5B Antibody (clone Hvjep-2)

Recombinant Mouse Anti-Human UNC5B Antibody (clone Hvjep-2) (CAT#: MOB-1239MZ)

This antibody is a recombinant mouse monoclonal antibody which specifically reacts with human UNC5B.

Gene Expression
Datasheet
MSDS
COA

Normal Tissue

Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_4_2_selected.jpg

Figure 2 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_B_8_5.jpg

Figure 3 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_8_5.jpg

Figure 4 Testis
(Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Leydig cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_6_6.jpg

Figure 5 Seminal vesicle
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_9_6.jpg

Figure 6 Lymph node
(Germinal center cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76687/166866_A_9_8.jpg

RNA Expression

Figure 7 RNA cell line category: Cell line enhanced (HaCaT, HHSteC, hTCEpi, SH-SY5Y)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107731-UNC5B

Datasheet

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Immunogen
Recombinant fragment, corresponding to amino acids 28-363 of Human UNC5B

Host Species
Mouse

Type
Mouse antibody

Specificity
Human UNC5B

Species Reactivity
Human

Clone
Hvjep-2

Applications
FC, ICC/IF

Target

Alternative Names
UNC5B; Human UNC5B

Gene ID
219699

UniProt ID
Q8IZJ1

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Human Antibody Products IgG Antibody Products ScFv Antibody Products Fab Antibody Products

CAT	Product Name	Application	Type
TAB-229CQ	Anti-Human UNC5B Recombinant Antibody (YW83.21)	ELISA, FC, WB	Human antibody
TAB-229CQ-S(P)	Anti-Human UNC5B Recombinant Antibody scFv Fragment (YW83.21)	ELISA, FC, WB	Human antibody
TAB-229CQ-F(E)	Anti-Human UNC5B Recombinant Antibody Fab Fragment (YW83.21)	ELISA, FC, WB	Human antibody

CAT	Product Name	Application	Type
HPAB-0058CQ	Human Anti-UNC5B Recombinant Antibody (clone YW88.82)	WB, FC, Block	Human IgG1, κ
HPAB-0059CQ	Human Anti-UNC5B Recombinant Antibody (clone YW83.7)	WB, FC	Human IgG1, κ
HPAB-AP840-YC	Human Anti-UNC5B Recombinant Antibody (clone AP014/YC)	ELISA, FC, WB	Human IgG
HPAB-AP841-YC	Human Anti-UNC5B Recombinant Antibody (clone AP015/YC)	ELISA, FC, WB	Human IgG
HPAB-AP842-YC	Human Anti-UNC5B Recombinant Antibody (clone AP016/YC)	ELISA, FC, WB	Human IgG

CAT	Product Name	Application	Type
HPAB-0058CQ-S(P)	Human Anti-UNC5B Recombinant Antibody (clone YW88.82); scFv Fragment	WB, FC, Block	Human scFv
HPAB-0059CQ-S(P)	Human Anti-UNC5B Recombinant Antibody (clone YW83.7); scFv Fragment	WB, FC	Human scFv
HPAB-AP840-YC-S(P)	Human Anti-UNC5B Recombinant Antibody (clone AP014/YC); scFv Fragment	ELISA, FC, WB	Human scFv
HPAB-AP841-YC-S(P)	Human Anti-UNC5B Recombinant Antibody (clone AP015/YC); scFv Fragment	ELISA, FC, WB	Human scFv
HPAB-AP842-YC-S(P)	Human Anti-UNC5B Recombinant Antibody (clone AP016/YC); scFv Fragment	ELISA, FC, WB	Human scFv

CAT	Product Name	Application	Type
HPAB-0058CQ-F(E)	Human Anti-UNC5B Recombinant Antibody (clone YW88.82); Fab Fragment	WB, FC, Block	Human Fab
HPAB-0059CQ-F(E)	Human Anti-UNC5B Recombinant Antibody (clone YW83.7); Fab Fragment	WB, FC	Human Fab
HPAB-0060CQ-F(E)	Human Anti-UNC5B Recombinant Antibody (clone YW83.4); Fab Fragment	WB, FC	Human Fab
HPAB-0061CQ-F(E)	Human Anti-UNC5B Recombinant Antibody (clone YW88.7); Fab Fragment	WB, FC, Block	Human Fab
HPAB-AP840-YC-F(E)	Human Anti-UNC5B Recombinant Antibody (clone AP014/YC); Fab Fragment	ELISA, FC, WB	Human Fab

Customer Reviews and Q&As

Customer Review Q&As

Reliable Research Tool

Using the Recombinant Anti-Human UNC5B Antibody has significantly streamlined my research. The antibody showed remarkable specificity and sensitivity in our flow cytometry experiments, consistently delivering reliable results.

Great Performance

Our transition to UNC5B antibodies from Creative Biolabs has been fantastic. The outstanding performance in ICC/IF applications has made complex interactions easier to visualize. Delivery was prompt, and the technical support provided exceeded expectations. Their expertise helped optimize our experiment protocols, ensuring top-notch results.

Versatile Application

The versatility of this antibody across multiple applications is impressive. It has adapted well in our antibody-coupled liposome development studies, proving its broad functional scope.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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