Anti-ABCC3 Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs is a drug metabolism and oncology expert provider of high-quality anti-ABCC3 recombinant antibodies. As a critical transporter for detoxification of bile acids and the metabolism of xenobiotics, ABCC3 is an essential component of hepatic function and one of the major contributors to the development of chemotherapeutic resistance. Creative Biolabs' validated anti-ABCC3 rAbs provide researchers studying hepatobiliary transport, drug disposition and multidrug resistance mechanisms with the high-quality antibody solution they need to advance their work.

ABCC3: A Basolateral Transporter in Drug and Bile Acid Efflux

ATP-binding cassette subfamily C member 3 (ABCC3), also known as Multidrug Resistance-Associated Protein 3 (MRP3), is a basolateral membrane efflux transporter of organic anions that is highly expressed in hepatocytes and intestinal cells. It transports a variety of glucuronidated and sulfated drug metabolites as well as bile acids, from the cytosol back into the circulation. Expression of ABCC3 is induced during cholestasis as part of a protective cellular response against the buildup of toxic bile acids in the liver. In the context of oncology, overexpression of MRP3 can also lead to resistance against many anticancer drugs, including etoposide and teniposide.

Alternative Names

ABCC3; ABC31; MLP2; Multi-Specific Organic Anion Transporter D; MRP3; Multidrug Resistance Associated Protein; EC 3.6.3; CMOAT2; EC 6.3.2.4; ATP-Binding Cassette Sub-Family C Member 3; EC 3.6.3.44; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3;

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Anti-ABCC3 rAb Products

Creative Biolabs' anti-ABCC3 recombinant antibodies are designed and validated to have high affinity and specificity, allowing for strong and specific detection of this crucial membrane transporter in difficult applications, such as IHC on liver and tumor tissue sections and Western Blotting of cell membrane fractions.

Table 1. Featured anti-ABCC3 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is at the forefront of antibody development for innovative research areas such as pharmacology and hepatology. We use the latest recombinant antibody expression platforms to produce high-quality, fully functional, and customized antibodies for your research. Our anti-ABCC3 recombinant antibodies are expressed in the optimized mammalian systems needed for recognition of the complex native transmembrane transporter, ensuring a highly active final product.

Featured Anti-ABCC3 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ABCC3 recombinant antibody production.

Fig.2 Gram-scale anti-ABCC3 recombinant antibody production.

rAb Modalities

Creative Biolabs' goal is to help power your science. To that end, we offer a broad range of customizable antibody modalities to help you work in the manner that best fits your research project. Our anti-ABCC3 recombinant antibodies are available in full-length IgG format for functional studies or conjugated formats for direct detection in cells, among other modalities.

Fig.3 Full-length anti-ABCC3 recombinant antibody production and modalities.

Creative Biolabs is your source for validated recombinant antibodies for studying the critical roles that ABCC3 play in detoxification and drug resistance. With consistent quality and reliability that has become our hallmark in the field, Creative Biolabs anti-ABCC3 rAbs are just one part of a broad range of antibody solutions and services to advance your toxicology and cancer research. Contact our technical support team today to get started.