Mouse Anti-ABCC3 Recombinant Antibody (VS3-FY2926) (CAT#: VS3-FY2926)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human ABCC3

• Species Reactivity
• Human

• Applications
• Western Blot, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 169.3 kDa.

• Related Disease
• Dubin-Johnson Syndrome and Cholestasis

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  ELISA: 1/1000-1/10000

• Alternative Names
• ATP Binding Cassette Subfamily C Member 3; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3; Canalicular Multispecific Organic Anion Transporter 2; Multi-Specific Organic Anion Transporter D; ATP-Binding Cassette Sub-Family C Member 3; Multidrug Resistance-Associated Protein 3; CMOAT2; MOAT-D; MLP2

• Gene ID
• 8714

• UniProt ID
• O15438

• Sequence Similarities
• Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

• Cellular Localization
• Basolateral cell membrane
  Multi-pass membrane protein
  Basal cell membrane
  Multi-pass membrane protein

• Post Translation Modifications
• Glycosylation at Asn18, Asn1006, and Asn1007 (NX_O15438 [NX_O15438-1])
  Modification sites at PhosphoSitePlus (O15438)
  Glycosylation from GlyGen (O15438) 4 sites, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_003777.2

• Function
• ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, 15083066, 10359813).
  Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4).

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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