Mouse Anti-ABCC3 Recombinant Antibody (VS3-FY2926) (CAT#: VS3-FY2926)
The anti-ABCC3 antibody is a mouse recombinant monoclonal antibody that is designed to selectively bind to human ABCC3 protein. The calculated molecular weight of the protein is about 169.3 kDa. The antibody can be utilized for detection of ABCC3 by Western Blot (1/500-1/2000) and ELISA (1/1000-1/10000).
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Subcellular Location and Protein Expression
Normal Tissue
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/864_G9_3_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/864_G9_3_selected.jpg
Figure 2 IHC staining of human gallbladder
(Immunohistochemical staining of human gallbladder shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37136/76790_A_4_4_selected.jpg
(Immunohistochemical staining of human gallbladder shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37136/76790_A_4_4_selected.jpg
Figure 3 Colon
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/135656_A_8_3.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/135656_A_8_3.jpg
Figure 4 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/135656_A_6_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/135656_A_6_6.jpg
Figure 5 Kidney
(Cells in glomeruli
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/135656_A_7_5.jpg
(Cells in glomeruli
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/135656_A_7_5.jpg
Figure 6 Gallbladder
(Glandular cells
Staining :High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/135656_A_6_4.jpg
(Glandular cells
Staining :High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48483/135656_A_6_4.jpg
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human ABCC3
- Species Reactivity
- Human
- Applications
- Western Blot, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 169.3 kDa.
- Related Disease
- Dubin-Johnson Syndrome and Cholestasis
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
ELISA: 1/1000-1/10000
Target
- Alternative Names
- ATP Binding Cassette Subfamily C Member 3; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3; Canalicular Multispecific Organic Anion Transporter 2; Multi-Specific Organic Anion Transporter D; ATP-Binding Cassette Sub-Family C Member 3; Multidrug Resistance-Associated Protein 3; CMOAT2; MOAT-D; MLP2
- Gene ID
- 8714
- UniProt ID
- O15438
- Sequence Similarities
- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
- Cellular Localization
- Basolateral cell membrane
Multi-pass membrane protein
Basal cell membrane
Multi-pass membrane protein
- Post Translation Modifications
- Glycosylation at Asn18, Asn1006, and Asn1007 (NX_O15438 [NX_O15438-1])
Modification sites at PhosphoSitePlus (O15438)
Glycosylation from GlyGen (O15438) 4 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_003777.2
- Function
- ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, 15083066, 10359813).
Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single Domain Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-18-sdAb | Recombinant Anti-Human ABCC3 VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
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