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ABCG1
Anti-ABCG1 Recombinant Antibody Products
- Rabbit Anti-ABCG1 Recombinant Antibody (clone CBACN-007) (MRO-0017-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Chicken Anti-ABCG1 Polyclonal IgY (BRD-0837MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.
Protein class
Metabolic proteins, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Rod photoreceptor cells, Syncytiotrophoblasts)
Immune cell specificity
Group enriched (neutrophil, eosinophil)
Cell line specificity
Cell line enhanced (hTCEpi, JURKAT, MCF7, MOLT-4, OE19, RPMI-8226)
Interaction
Homodimer; disulfide-linked (PubMed:16702602). Homooligomer (PubMed:16702602). May form heterodimers with several heterologous partners of the ABCG subfamily. Forms heterodimers with ABCG4 (PubMed:27228027). Interacts with CAV1; this interaction regulates ABCG1-mediated cholesterol efflux (PubMed:24576892).
Molecular function
Translocase
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