Anti-ACACA Recombinant Antibody Products

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Anti-ACACA Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in developing premium recombinant antibodies against ACACA to propel biomedical breakthroughs. Through our advanced technological platforms, we guarantee superior product quality and consistent performance for critical research applications. We offer an expansive selection of meticulously engineered biologics that combine outstanding reliability with cost-effectiveness. Beyond supplying these research tools, our team provides customized technical guidance and troubleshooting expertise throughout your project lifecycle. Choosing Creative Biolabs means partnering with scientists who are equally invested in helping you achieve meaningful discoveries through tailored antibody solutions and collaborative support.

ACACA: A Pivotal Metabolic Regulator in Cancer Diabetes and Neurological Disorders

As a central regulator of lipid metabolism, ACACA serves as a critical node in multiple disease pathways through its control of de novo fatty acid synthesis. This metabolic gatekeeper's dysregulation manifests across diverse pathological conditions, with particularly strong associations observed in oncological and metabolic diseases. In cancer biology, hyperactivity fuels tumor progression by supplying building blocks for membrane biosynthesis and post-translational modifications that drive oncogenic signaling. The enzyme's metabolic influence extends to type 2 diabetes, where its overactivity in liver tissue exacerbates hyperlipidemia and contributes to insulin resistance pathogenesis. Cardiovascular studies reveal its involvement in endothelial dysfunction through mechanisms involving lipid-induced oxidative stress and foam cell formation. Emerging neurological research suggests potential links to Alzheimer's pathology, possibly through effects on neuronal membrane composition and synaptic vesicle formation. Therapeutically, modulation of this enzymatic activity presents both opportunities and challenges, as systemic inhibition risks disrupting essential physiological processes while targeted approaches show promise in preclinical models. These multifaceted disease connections continue to motivate investigation into selective regulatory strategies that could yield novel treatments for conditions ranging from malignancies to metabolic syndrome.

Alternative Names

Complement ACC; ACAC; ACC1; ACCA; Acac1; hACC1; ACACAD; ACCalpha; ACACalpha

Background

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Anti-ACACA rAb Products

We accelerate scientific breakthroughs by providing premium anti-ACACA antibodies that combine exceptional performance with cost-effectiveness. Our offerings are backed by comprehensive technical expertise and personalized support throughout your research journey, ensuring reliable results and efficient progress in your studies.

Table 1. Featured anti-ACACA recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

C**an
Rabbit Anti-ACACA Recombinant Antibody (clone ST53-08) (CAT#: VS3-WK797)

The ST53-08 clone has worked reliably in our metabolic studies. We've successfully used it for IHC on frozen sections of mouse adipose tissue, showing clear cytoplasmic staining at 1:200 dilution. While it performs well in western blots with liver homogenates, we noticed some background in heart tissue samples. The antibody worked better with antigen retrieval in formalin-fixed paraffin-embedded samples compared to other clones we've tried.

05/Jan/2024

Excellent

Ma**o
Mouse Anti-ACACA Recombinant Antibody (VS3-CJ103) (CAT#: VS3-CJ103)

The VS3-CJ103 antibody has become our reliable choice for ACACA detection. In ELISA assays with liver tissue lysates, it consistently produced clean standard curves at 1:3000 dilution. We've also had success with IHC in mouse adipose sections, though antigen retrieval optimization was needed for best results. The antibody showed good specificity in HEK293T cell lysates during western blotting, with minimal cross-reactivity. While slightly more expensive than some alternatives, its batch-to-batch consistency has saved us troubleshooting time.

18/Apr/2024

Excellent

Ly**a
Mouse Anti-ACACA Recombinant Antibody (clone 37G1) (CAT#: MOB-4059z)

We initially had doubts about clone 37G1 after some mixed reviews, but it's proven surprisingly robust in our hands. While it struggled with certain cancer cell lines, it performed beautifully in WB with differentiated 3T3-L1 adipocytes at 1:800 dilution. The real surprise came when we tried it on Drosophila samples - picked up the ortholog cleaner than any other clone we've tested.

11/Nov/2023

rAb Production

With decades of specialized experience in antibody engineering and optimization, we've refined our processes to consistently manufacture premium-grade recombinant antibodies with exceptional reliability. Our streamlined workflows enable rapid production without compromising quality, supported by a dedicated scientific team committed to delivering tailored solutions that precisely meet your research requirements within accelerated timelines.

Featured Anti-ACACA Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

At Creative Biolabs, we specialize in developing innovative antibody solutions across diverse formats to support cutting-edge research. Leveraging advanced protein engineering technologies and novel design strategies, we deliver meticulously crafted biologics that meet rigorous performance standards. Each product is supported by tailored development services, ensuring optimal compatibility with your experimental requirements and research objectives while maintaining exceptional quality and reliability.

Fig.3 Full Length Anti-ACACA Recombinant Antibody Production and Modalities.

For ACACA-related questions or technical support, please contact us anytime – our specialists are ready to help optimize your research. We provide customized guidance on experimental design, troubleshooting, and data interpretation to ensure your project's success. Whether you're establishing new protocols or refining existing ones, our team offers the expertise you need at every stage.