Anti-ACAT2 Recombinant Antibody Products

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Anti-ACAT2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in developing premium ACAT2-targeting antibodies through advanced recombinant technologies, engineered to meet rigorous quality benchmarks for lipid metabolism research. Our optimized production platform delivers high-specificity reagents with exceptional batch-to-batch consistency, complemented by comprehensive scientific support spanning experimental design, protocol optimization, and data interpretation. Researchers benefit from our expanding portfolio of validated antibody formulations, each offering reliable performance across diverse applications. Beyond products, we provide tailored partnership solutions to address complex challenges in atherosclerosis and metabolic disorder studies, combining technical expertise with flexible customization options to accelerate your research timeline while maintaining cost-effectiveness.

ACAT2: A Key Modulator in Atherosclerosis Cancer and Metabolic Disorders

ACAT2 plays a pivotal role in cholesterol esterification, with its dysregulation implicated in multiple metabolic and cardiovascular pathologies. In atherosclerosis, elevated activity promotes foam cell formation by esterifying free cholesterol in macrophages, accelerating plaque development and vascular inflammation. The enzyme's intestinal expression links it to hypercholesterolemia, where excessive cholesterol absorption exacerbates circulating LDL levels. Oncological studies associate its overexpression with hepatocellular carcinoma progression, facilitating lipid droplet accumulation that supports tumor microenvironment remodeling. Metabolic syndrome research demonstrates that inhibition improves insulin sensitivity by reducing hepatic lipid deposition and systemic inflammation. Genetic studies connect loss-of-function variants to reduced coronary artery disease risk, highlighting its therapeutic potential. Autoimmune investigations reveal its involvement in lipid antigen presentation, modulating T-cell responses in diseases like multiple sclerosis. Current therapeutic strategies explore selective inhibitors for cardiovascular protection, while siRNA approaches show promise in targeting hepatic production. Its tissue-specific effects—hepatic versus intestinal—create unique intervention opportunities for metabolic disorders without systemic toxicity. The convergence of these pathways positions it as a multifaceted target for conditions where cholesterol metabolism intersects with inflammation, cancer, and metabolic dysregulation, with several investigational compounds now in clinical trials.

Alternative Names

Complement Acetyl-CoA Acetyltransferase 2; EC 2.3.1.9; Acetyl-Coenzyme A Acetyltransferase 2 (Acetoacetyl Coenzyme A Thiolase); Acetyl-Coenzyme A Acetyltransferase 2; Acetyl-CoA Transferase-Like Protein; Cytosolic Acetoacetyl-CoA Thiolase; Acetoacetyl Coenzyme A Thiolase; EC 2.3.1; ACTL

Background

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-ACAT2 rAb Products

Advancing research on ACAT2 is our priority, achieved by offering high-quality recombinant antibodies that merge strict validation with affordable options. Our expert team delivers customized assistance throughout your experiments—from target confirmation to analysis of findings—guaranteeing dependable outcomes for investigations into atherosclerosis, metabolic diseases, and related fields.

Customer Reviews

Excellent

Ly**a
Mouse Anti-ACAT2 Recombinant Antibody (clone 29H5) (CAT#: MOB-3714z)

The Mouse Anti-ACAT2 worked well in ELISA with recombinant protein, showing good linear detection between 1-10 ng/mL. In WB, it detected a clean ~50kDa band in liver lysates at 1:1000 dilution, though intestinal samples required longer blocking. Some lot-to-lot variability was noted in low-abundance samples. Suitable for basic ACAT2 detection when optimized.

03/Mar/2024

Excellent

Z**ne
Mouse Anti-NHP ACAT2 Recombinant Antibody (VS-1024-XY3) (CAT#: VS-1024-XY3)

Tested the Mouse Anti-NHP ACAT2 in WB with rhesus liver samples - clean 50kDa band at 1:800 dilution with 5% BSA blocking. Showed weaker signal in intestinal lysates requiring increased primary antibody concentration. Performed consistently across three lots in primate tissues. Not validated for IP applications. Works as expected for NHP studies when protocol is adjusted for tissue type.

24/Jul/2024

rAb Production

With over a decade of specialized experience in antibody development, we've optimized our platform to deliver premium recombinant antibodies that combine rigorous quality control with rapid turnaround times. Our customer-focused approach ensures each batch undergoes extensive validation while maintaining cost-effectiveness for research budgets, supported by responsive technical consultation.

Featured Anti-ACAT2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ACAT2 recombinant antibody production.

Fig.2 Gram-scale anti-ACAT2 recombinant antibody production.

rAb Modalities

Creative Biolabs specializes in delivering premium engineered antibody solutions across diverse formats, leveraging advanced molecular design technologies to address complex research challenges. Our expertise spans multiple antibody engineering platforms, complemented by fully customizable development services that combine rigorous quality standards with flexible customization options tailored to your experimental requirements.

Fig.3 Full Length Anti-ACAT2 Recombinant Antibody Production and Modalities

For detailed technical guidance on ACAT2 research applications or protocol optimization, please contact our scientific support team. Our specialists provide personalized consultation to troubleshoot experimental challenges and ensure reliable results for your lipid metabolism studies, from antibody selection to data interpretation.