Anti-ACSS1 Recombinant Antibody Products

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Anti-ACSS1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in developing high-specificity recombinant antibodies targeting ACSS1, engineered through our proprietary protein expression platforms to meet rigorous validation standards for metabolic research. We offer an expanding portfolio of optimized antibody formulations, each validated for consistency across applications including immunohistochemistry, flow cytometry, and functional assays. Beyond product excellence, our scientific team provides end-to-end support—from target validation to experimental design—helping researchers overcome technical challenges in acetyl-CoA metabolism studies while maintaining cost-effective solutions and rapid turnaround times.

ACSS1: A Metabolic Regulator Linking Cancer Cachexia Neurodegeneration and Fibrosis

ACSS1 serves as a critical metabolic node in acetyl-CoA synthesis, with dysregulation implicated in diverse pathological processes. In hepatocellular carcinoma, upregulated activity fuels lipogenesis and histone acetylation, promoting tumor proliferation and chemoresistance through epigenetic reprogramming. The enzyme's neuronal expression links it to neurodegenerative disorders, where deficient acetate metabolism exacerbates synaptic dysfunction in Alzheimer's models. Cardiovascular studies demonstrate its role in cardiac fibrosis, with enhanced activity driving fibroblast activation via acetyl-CoA-dependent collagen production. Metabolic syndrome research reveals that tissue-specific inhibition improves insulin sensitivity by normalizing lipid partitioning between liver and adipose depots. Emerging oncology data highlight its involvement in cancer cachexia, where systemic acetate scavenging by tumors disrupts muscle protein homeostasis. Autoimmune investigations suggest modulation of this pathway influences Treg cell function through acetylation-dependent Foxp3 stabilization. Therapeutic strategies currently explore selective inhibitors for oncology applications, while substrate supplementation approaches show promise for neurological indications. Its dual cytoplasmic and nuclear localization creates unique opportunities for targeting metabolic-epigenetic crosstalk in diseases where acetyl-CoA flux dictates pathological outcomes. The convergence of these mechanisms positions it as a multifaceted target across oncology, neurology, and metabolic disorders, with several investigational compounds now entering clinical evaluation.

Alternative Names

Complement ACAS2L; ACECS1; AceCS2L

Background

An acetyl-CoA synthetase found in the mitochondrial matrix has been characterized in both cow and mouse. It is primarily a cardiac enzyme which produces acetyl-CoA mainly for the oxidation of acetate. The protein encoded by this gene is structurally similar to the cow and mouse proteins and therefore may serve a similar function in humans.

Anti-ACSS1 rAb Products

We are committed to speeding up research and discovery by offering anti-ACSS1 recombinant antibody products of the highest quality, excellent value, and top-notch technical support.

Table 1. Featured anti-ACSS1 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

Ka**s
Mouse Anti-ACSS1 Recombinant Antibody (VS3-CJ5) (CAT#: VS3-CJ5)

The Mouse Anti-ACSS1 antibody performed well in ELISA with recombinant protein and detected endogenous protein in HepG2 lysates by WB at 1:1000 dilution. While it showed clean 75kDa bands in liver tissue, we observed weaker signals in neuronal samples requiring longer exposures. Some lot-to-lot variability was noted in low-abundance samples. Suitable for basic detection when optimized, though not yet tested in IP applications.

15/Jan/2024

Excellent

M**ld
Mouse Anti-ACSS1 Recombinant Antibody (clone 3A7C1) (CAT#: VS7-HM18)

Tested the Mouse Anti-ACSS1 in IHC with cardiac tissue - showed specific nuclear staining at 1:150 dilution after citrate buffer retrieval. Performed consistently in human heart failure samples but required longer blocking in fibrotic areas. Cross-reacted weakly with rodent tissues. Works reliably for clinical FFPE specimens when protocols are carefully optimized.

09/Aug/2023

rAb Production

With extensive experience spanning multiple years in the field of recombinant antibody development and optimization, we specialize in delivering exceptional services that ensure the highest-quality antibody products. Our commitment to excellence enables us to achieve outstanding results within the shortest possible turnaround time, maintaining rigorous standards throughout the process.

Featured Anti-ACSS1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing scientists with a comprehensive selection of cutting-edge recombinant antibodies in diverse formats. Leveraging deep expertise in antibody engineering, we employ advanced methodologies to develop high-performance solutions. Our offerings are supported by bespoke customization services, ensuring each product aligns precisely with your research requirements.

Fig.3 Full Length Anti-ACSS1 Recombinant Antibody Production and Modalities

For further details on the ACSS1 target, please don't hesitate to contact our experts by phone or email. Our experienced team is eager to provide guidance and resolve any experimental inquiries or technical difficulties, offering dedicated assistance to help you achieve optimal results in your research endeavors.