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ADRB2
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Protein class
FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Basal keratinocytes, Squamous epithelial cells, Suprabasal keratinocytes, Adipocytes, Basal respiratory cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (hTCEpi, hTERT-HME1, PC-3)
Interaction
Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (PubMed:9924018). Interacts with USP20 and USP33 (PubMed:19424180, PubMed:23166351). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262). Interacts with NEDD4 (PubMed:23166351). Interacts with MARCHF2 (PubMed:23166351).
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
- Rabbit Anti-ADRB2 Recombinant Antibody (clone JM102-06) (MRO-0167-CN)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, IHC, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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- Derivation: Llama
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
-
- Species Reactivity: Human
- Type: Llama VHH
- Application: ELISA
-
- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, FuncS
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, FuncS
- Recombinant Llama Anti-ADRB2 Antibody (PABL-393)
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- Derivation: Llama
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, FuncS
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
-
- Derivation: Llama
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA
-
- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, ELISA, FuncS
- Mouse Anti-ADRB2 Antibody (clone mAb5), mRNA (PABW-007-mRNA)
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- Species Reactivity: Human
-
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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- Species Reactivity: Human
- Type: Camelid VHH
- Application: ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA
- Camelid Anti-ADRB2 Recombinant Single Domain Antibody (Nb71) (NBD-0087-YJ-VHH)
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- Species Reactivity: Human
- Type: Camelid VHH
- Application: ELISA
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- Type: Mouse IgG1
- Application: FC
- Chicken Anti-β-2 Adrenergic Receptor Polyclonal IgY (BRD-0027MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.