PDZ domain scaffold protein anti-Human β1-adrenergic receptor

CAT#: SPD-L174

The PDZ domain that bound β1-adrenergic receptor was isolated from the library using Yeast Two-hybrid techonology. PDZ domains are modular protein-interaction domains that are specialized for binding to short peptide motifs at the extreme carboxy (C) termini of other proteins, athough they can also have other modes of interaction. After affinity maturation, PDZ domain variants were identified having affinities (KD=50 nM) for β1-adrenergic receptor as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

Gene Expression
Figure 1 IF staining of human cell line A-431 Figure 2 IHC staining of human pancreas Figure 3 Colon Figure 4 Liver Figure 5 Kidney Figure 6 Testis Figure 7 Cervix Figure 8 RNA cell line category: Cell line enhanced (hTCEpi, hTERT-HME1, PC-3)

Specifications

  • Scaffold Name
  • PDZ domain
  • Origin
  • PSD-95 protein
  • Core Structure
  • β-sheet
  • Target
  • β1-adrenergic receptor
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Affinity Constant
  • 50 nM

Target

  • Alternative Names
  • PSD-95 protein; PDZ domain; BAR; B2AR; ADRBR; ADRB2R; BETA2AR
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