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PDZ domain anti-ADRB2 (SPD-L174)

The PDZ domain that bound β1-adrenergic receptor was isolated from the library using Yeast Two-hybrid techonology. PDZ domains are modular protein-interaction domains that are specialized for binding to short peptide motifs at the extreme carboxy (C) termini of other proteins, athough they can also have other modes of interaction. After affinity maturation, PDZ domain variants were identified having affinities (KD=50 nM) for β1-adrenergic receptor as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      
Datasheet
Specifications
Scaffold Name
PDZ domain
Origin
PSD-95 protein
Core Structure
β-sheet
Target
β1-adrenergic receptor
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
50 nM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
PSD-95 protein; PDZ domain; BAR; B2AR; ADRBR; ADRB2R; BETA2AR
Entrez Gene ID
154
UniProt ID
P07550

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Recombinant Anti-Human ADRB2 VHH Single Domain Antibody (BI167107)    ( PNBL-001 )
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