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AEBP1
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma.
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Peritubular cells, Fibroblasts, Smooth muscle cells, Leydig cells, Endometrial stromal cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enhanced (ASC diff, BJ, BJ hTERT+, fHDF/TERT166, JURKAT, WM-115)
Interaction
Isoform 1: Interacts with different types of collagen, including collagens I, III, and V (PubMed:29606302). Isoform 2: Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. Interaction with MAPK1 may stimulate DNA-binding. May interact with calmodulin. Binds to DNA in vitro.
Molecular function
Calmodulin-binding, DNA-binding, Repressor
More Types Infomation
- PE-A*69:01/Human AEBP1 (ETEQPTLDY) MHC Tetramer (MHC-LC4446)
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- Class: Class I
- Antigen: AEBP1
- Antigen Species: Human
- Peptide: ETEQPTLDY
- Conjugate: PE
- PE-A*01:01/Human AEBP1 (ETEQPTLDY) MHC Tetramer (MHC-LC4445)
-
- Class: Class I
- Antigen: AEBP1
- Antigen Species: Human
- Peptide: ETEQPTLDY
- Conjugate: PE
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: IHC-P, WB
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For Research Use Only. Not For Clinical Use.