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AHR
Loading...Anti-AHR Products
- Mouse Anti-AHR Recombinant Antibody (clone 36D6) (MOB-2225z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC, IP
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- Rabbit Anti-AHR Recombinant Antibody (clone JM34-10) (MRO-0123-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF
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- Anti-AHR Immunohistochemistry Kit (VS-0325-XY65)
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- Species Reactivity: Human, Mouse, Rat
- Target: AHR
- Application: IHC
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- Rabbit Anti-AHR Recombinant Antibody (VS13-YC34) (VS13-YC34)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (hTCEpi, hTERT-HME1, OE19, RT4)
Interaction
Homodimer (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:10395741, PubMed:28602820). Interacts with ARNT; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). Binds MYBBP1A (By similarity). Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT (PubMed:10395741). Interacts with NEDD8 and IVNS1ABP (PubMed:12215427, PubMed:16582008). Interacts with ARNTL/BMAL1 (By similarity). Interacts with HSP90AB1 (By similarity). Interacts with TIPARP; leading to mono-ADP-ribosylation of AHR and subsequent inhibition of AHR (PubMed:23275542, PubMed:30373764).
Molecular function
Activator, DNA-binding, Receptor, Repressor
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