Anti-AHR Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a trusted supplier in the toxicology, immunology, and oncology fields. We are well known for the high quality of our anti-Aryl Hydrocarbon Receptor (AHR) recombinant antibodies. As a master regulator of inflammation and cell fate, AHR is a critical sensor of environmental and endogenous cues. Our specific antibodies will allow you to fully dissect the role of AHR signaling in tumor immunity, autoimmune disease, and toxicology.

AHR: A Ligand-Activated Sensor Bridging Environment and Immunity

The Aryl Hydrocarbon Receptor (AHR) is a ligand-activated transcription factor that is localized to the cytosol. Long known for its role in mediating the toxic effects of environmental pollutants like dioxins, it has become apparent that AHR is also capable of binding a large number of endogenous ligands, including metabolites of tryptophan. In this way, AHR is a critical sensor of the tissue microenvironment. AHR signaling has profound effects on the differentiation of immune cell subsets, especially T cells (Th17/Treg balance) and innate lymphoid cells. It is frequently dysregulated in various cancers and autoimmune diseases and is an exciting therapeutic target.

Alternative Names

AHR; BHLHe76; Aryl Hydrocarbon Receptor; AH-Receptor; Ah Receptor; Class E Basic Helix-Loop-Helix Protein 76; Aromatic Hydrocarbon Receptor; AhR

Background

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]

Anti-AHR rAb Products

Our anti-AHR recombinant antibodies are designed to provide unmatched specificity and performance for your most critical assays. Meticulously validated, our AHR rAbs will detect AHR in nuclear and cytosolic fractions, clearly resolving receptor activation and translocation. Optimized for ChIP-seq, Western Blot, and immunofluorescence, Creative Biolabs' AHR rAbs will give you the sensitivity and specificity you need to fully dissect this complicated signaling pathway.

Table 1. Featured anti-AHR recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is on the leading edge of the rapidly advancing fields of immunology and oncology. We use state-of-the-art recombinant antibody production technologies to give you the best products available. Our anti-AHR recombinant antibodies are expressed in an optimized system that allows them to faithfully recognize the native receptor, giving you a specific and active tool for your most sensitive applications.

Featured Anti-AHR Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-AHR recombinant antibody production.

Fig.2 Gram-scale anti-AHR recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to being an innovative and responsive partner for the scientific community. We understand the importance of flexibility, which is why we offer our anti-Aryl Hydrocarbon Receptor (AHR) recombinant antibodies in a variety of customizable modalities to meet the needs of your unique experimental designs. Help your research advance by empowering your investigations of this important environmental sensor and therapeutic target.

Fig.3 Full-length anti-AHR recombinant antibody production and modalities.

Decode the complex biology of the Aryl Hydrocarbon Receptor (AHR) with Creative Biolabs' superior recombinant antibodies. Meticulously validated and designed for unmatched specificity and performance, our portfolio provides you with the ideal tools to support your most important work in immunology and oncology. Choose Creative Biolabs to help power your next breakthrough. Contact our experts today.