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AIRE
Loading...Anti-AIRE Products
- Rabbit Anti-AIRE Polyclonal Antibody (MRO-1670-CN) (MRO-1670-CN)
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: WB
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- Rabbit Anti-AIRE Polyclonal Antibody (MRO-1671-CN) (MRO-1671-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, FC
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- Rabbit Anti-AIRE Polyclonal Antibody (MRO-1672-CN) (MRO-1672-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Anti-AIRE Immunohistochemistry Kit (VS-0325-XY73)
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- Species Reactivity: Human, Mouse, Rat
- Target: AIRE
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Microglial cells, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Homodimer and homotetramer. Interacts with CREBBP. Interacts preferentially with histone H3 that is not methylated at 'Lys-4'. Binds with lower affinity to histone H3 that is monomethylated at 'Lys-4'. Trimethylation of histone H3 at 'Lys-4' or phosphorylation at 'Thr-3' abolish the interaction. Binds with lower affinity to histone H3 that is acetylated at 'Lys-4', or that is acetylated at 'Lys-9' or trimethylated at 'Lys-9'. Binds histone H3 that is dimethylated at 'Arg-2' with very low affinity.
Molecular function
Activator, DNA-binding
More Types Infomation
Related Diseases
Primary Immunodeficiency