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AKR1C3
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Exocrine glandular cells, Proximal tubular cells, Proximal enterocytes, Basal respiratory cells)
Immune cell specificity
Group enriched (basophil, gdT-cell)
Cell line specificity
Cell line enhanced (A549, ASC diff, Hep G2, OE19, RT4)
Molecular function
Oxidoreductase
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IHC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IF, FC
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For Research Use Only. Not For Clinical Use.