Enzymes, FDA approved drug targets, Metabolic proteins
Intracellular
Cell type enhanced (granulocytes, Macrophages, Hofbauer cells, Kupffer cells, B-cells, monocytes)
Low immune cell specificity
Cell line enhanced (BEWO, Daudi, HMC-1, U-266/70, U-698)
Homodimer (PubMed:22516296, PubMed:21233389). Interacts with ALOX5AP and LTC4S (PubMed:19233132). Interacts with COTL1, the interaction is required for stability and efficient catalytic activity (PubMed:19807693). Interacts with PIK3R1; this interaction bridges ALOX5 with CD40 after CD40 ligation in B cells and leads to the production of reactive oxygen species (ROS) (PubMed:21200133). Interacts (via PLAT domain) with DICER1 (via Dicer dsRNA-binding fold domain); this interaction enhances arachidonate 5-lipoxygenase activity and modifies the miRNA precursor processing activity of DICER1 (PubMed:19022417).
Dioxygenase, Hydrolase, Oxidoreductase
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For Research Use Only. Not For Clinical Use.