Anti-ANXA5 Products

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For Research Use Only. Not For Clinical Use.

Apoptosis and vascular biology research require high-quality antibodies. Creative Biolabs is here to assist with that with our superior anti-Annexin A5 (ANXA5) recombinant antibodies. ANXA5 is a well-known biomarker for apoptosis detection. Our high-quality anti-ANXA5 recombinant antibodies and conjugates are the perfect tools for apoptosis and coagulation researchers. They are designed to detect ANXA5 expression with exceptional accuracy and reliability for a wide variety of applications.

ANXA5: The Hallmark of Apoptosis and a Regulator of Coagulation

Annexin A5 (ANXA5) is a member of the annexin protein family and is characterized by its high binding affinity to phosphatidylserine (PS), a phospholipid that flips to the outside of the cell membrane in early apoptosis. It is a phospholipid-binding protein and for this reason, it is considered the gold standard biomarker for the detection of apoptotic cells by flow cytometry and other techniques. ANXA5 also acts as a natural anticoagulant by binding PS residues on activated platelets and endothelial cells. Abnormal ANXA5 expression is known to be involved in the development of autoimmune diseases such as antiphospholipid syndrome and thrombosis.

Alternative Names

PP4; ANX5; ENX2; CPB-I; RPRGL3; HEL-S-7; VAC-alph

Background

The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications.

Anti-ANXA5 rAb Products

Creative Biolabs’ anti-ANXA5 recombinant antibodies are of the highest quality. Engineered for peak performance, our anti-ANXA5 antibodies provide superior specificity and sensitivity for the detection of ANXA5 expression on a variety of platforms. Additionally, we offer the flexibility of directly conjugated ANXA5 proteins (FITC, Biotin) for use in apoptosis detection assays. Using Creative Biolabs’ anti-ANXA5 antibody and conjugated ANXA5 proteins will provide your research with low background and high-resolution results.

Table 1. Featured anti-ANXA5 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Our mission is to support the scientific community with high-quality, innovative products and we take that very seriously. Creative Biolabs has a strict quality control process for all antibodies. Every lot of our anti-ANXA5 recombinant antibody as well as conjugated ANXA5 proteins is fully validated for performance in the lab.

Customer Reviews

rAb Production

Creative Biolabs uses the latest in antibody production technologies to create our high-grade anti-ANXA5 reagents. Our recombinant ANXA5 antibodies and proteins are expressed in optimized systems to ensure the production of the highest purity protein with the correct fold and conformation for maximum biological activity.

Featured Anti-ANXA5 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-ANXA5 recombinant antibody production.

Fig.3 Gram-scale anti-ANXA5 recombinant antibody production.

rAb Modalities

Creative Biolabs has a wide range of ANXA5 antibodies and proteins to accommodate all the needs of apoptosis and coagulation research. We have unconjugated recombinant antibodies in different formats (full IgG, single chain variable fragment, scFv) as well as directly conjugated ANXA5 proteins to antibodies and other proteins. We also have a wide variety of directly conjugated ANXA5 proteins (FITC, Biotin, etc.) for plug-and-play apoptosis detection assays for our global customer base.

Fig.4 Full-length anti-ANXA5 recombinant antibody production and modalities.

If you are researching apoptosis, coagulation or related fields, it is essential to use the most effective tools available for a clear, high-resolution result. Creative Biolabs’ industry-leading anti-ANXA5 recombinant antibodies and reagents are your best choice. All of our products are fully validated and created with only the highest standards in quality control. Creative Biolabs has the tools and reagents to be the solution for your next success. Contact us today to find out how our products can benefit you.