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APOL1

Anti-APOL1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs uses advanced platforms to offer a diverse range of APOL1-targeted recombinant antibodies to customers worldwide. We are committed to providing exceptional, top-tier solutions that are tailored to our customers' specific needs. By constantly pushing the boundaries of research and innovation, we provide unrivaled technical support and service excellence, allowing our customers to achieve their scientific objectives efficiently and effectively.

APOL1: An Effective Target in Kidney Diseases

Apolipoprotein L1 (apoL1) is a minor component of HDL cholesterol, produced in the liver and various other tissues such as the pancreas, kidney, and brain. Each person carries two copies of the APOL1 gene, which are associated with an elevated risk of nondiabetic kidney disease and idiopathic focal segmental glomerulosclerosis (FSGS). Thus, APOL1 is recognized as a "kidney-risk" gene in specific populations, at the same time targeting APOL1 through precise therapeutics is crucial for the effective treatment of related kidney diseases.

Alternative Names

APOL1; APOL; APO-L; APOL; APOL-I; Apolipoprotein L; apolipoprotein L, 1; apolipoprotein L1; Apolipoprotein L-I; FSGS4; apolipoprotein L1-B3.

Background

This gene encodes a secreted high-density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes the efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.
Protein class

Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Glandular and luminal cells, Hepatocytes, Endometrial ciliated cells, Pancreatic endocrine cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (EFO-21, HDLM-2, HHSteC, RPTEC TERT1, RT4)

Interaction

In plasma, interacts with APOA1 and mainly associated with large high density lipoprotein particles.

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Anti-APOL1 Recombinant Antibody Products

Here is a selection of top-notch recombinant antibody products offered by Creative Biolabs. Our antibodies are renowned for their outstanding sensitivity, specificity, and purity, guaranteeing the highest quality in product delivery. We provide these products on a global scale to support research and innovation, while also offering excellent technical assistance to our customers.

Cat. No. Product Name Target Species Host Species Applications
MOR-0218 Hi-Affi™ Rabbit Anti-APOL1 Recombinant Antibody (clone DS218AB) Human Rabbit IgG FC, ICC, IP, WB
MOB-0687MZ Mouse Anti-APOL1 Recombinant Antibody (clone 2E5) Human Mouse IgG1 ELISA, WB
VS3-XY86 Mouse Anti-APOL1 Recombinant Antibody (clone 1D4) Human Mouse IgG1 ELISA, WB
ZG-0302F Mouse Anti-ApoL1 Recombinant Antibody (ZG-0302F) Human Mouse IgG ELISA, WB

Creative Quality Control

Our dedication is to advance research and development by providing unparalleled product quality and exceptional support, empowering the biopharmaceutical community. We ensure that customer satisfaction is our top priority by vigilantly upholding a comprehensive quality management system. This guarantees that our products not only satisfy but exceed industry standards, thereby simplifying the drug development process and providing our customers with superior value.

Fig.1 WB analysis of anti-APOL1 recombinant antibody (ZG-0302F). (Creative Biolabs Original)Fig.1 Anti-APOL1 Recombinant Antibody in WB.
(Cat# ZG-0302F, Creative Biolabs).

Customer Reviews

Excellent
Mi***a
Mouse Anti-APOL1 Recombinant Antibody (clone 2E5) (CAT#: MOB-0687MZ)
Application: Western blot
Sample: RCC-7860 whole cell lysate.
By following the recommended dilution and sample loading volume in the instructions, I achieved development results that displayed clear and specific bands, with no interference from the background. And, the batches can maintain a high level of consistency. This antibody from Creative Biolabs performs excellence in my opinion.
7/Aug/2023
Excellent
Rá***o
Mouse Anti-APOL1 Recombinant Antibody (clone 1D4) (CAT#: VS3-XY86)
I am satisfied with my recent purchase of the Anti-APOL1 Recombinant Antibody for use in an ELISA analysis. The excellent specificity and sensitivity of the antibody let us measure APOL1 in our samples more effectively. The assay approach was straightforward, and careful instructions were valued. This product has greatly enhanced the APOL1 research in our lab and I highly recommend it to anybody requiring reliable, premium antibodies for testing. Five stars.
11/Jun2024
Excellent
Al***e
Hi-Affi™ Rabbit Anti-APOL1 Recombinant Antibody (clone DS218AB) (CAT#: MOR-0218)
I recently tried out the Anti-APOL1 Recombinant Antibody for my Immunofluorescence (IF) assays, and I'm extremely pleased with the results. I was really impressed with the specificity and sensitivity of this antibody. It made it so easy for me to detect APOL1 in my samples, and the results were incredibly clear. The staining exhibited a vibrant and uniform appearance throughout various experiments, ensuring straightforward and dependable interpretation.
In addition, the provided protocol was straightforward to follow, and the antibody performed excellently under standard IF conditions without the need for any adjustments.
26/Jun/2024

Anti-APOL1 Recombinant Antibody Production

Our cutting-edge bioproduction facilities (serum-free mammalian cell expression platform) support comprehensive solutions, from gene synthesis to high-yield bulk production of anti-APOL1 recombinant antibodies. Leveraging our deep expertise and proven methodologies, we deliver cost-effective and rapid turnaround services, tailored to meet the diverse needs of our customers without compromising on quality.

Featured Anti-APOL1 Recombinant Antibody Production Platforms Fig.2 Anti-APOL1 recombinant antibody production: Milligram-scale. (Creative Biolabs Original)
Fig.2 Milligram-scale anti-APOL1 recombinant antibody production.

Fig.3 Anti-APOL1 recombinant antibody production: Gram-scale. (Creative Biolabs Original)Fig.3 Gram-scale anti-APOL1 recombinant antibody production.

Anti-APOL1 Recombinant Antibody Modalities

Creative Biolabs is dedicated to supporting the research community with an extensive array of cutting-edge recombinant antibodies. We specialize in developing anti-APOL1 antibodies in diverse formats such as full-length, Fab, and scFv. Leveraging our expertise in antibody engineering, we are well-prepared to provide customized solutions that meet the specific needs of your research projects.

Fig.4 The production and modalities of full-length anti-APOL1 recombinant antibody. (Creative Biolabs Original)Fig.4 Full-Length Anti-APOL1Recombinant Antibody Production and Modalities.

APOL1-Targeted Drug Information

Table 1. APOL1-targeted drug information.

Company Highest Phase Classification Condition
Immatics (Originator) Phase III Cancer Immunotherapy
Cancer Vaccines
Peptides
Peptide Vaccines
Cancer, kidney (renal cell carcinoma)
Cancer, kidney (renal cell carcinoma, clear cell)
Maze Therapeutics (Originator) Phase I Renal Disorders
AstraZeneca
Ionis Pharmaceuticals (Originator)
Phase I Antisense Therapy
Single-stranded oligodeoxyribonucleotide (DNA)
Chronic kidney disease
Nephropathy
Renal and urinary system genetic disorders
OmniAb (Originator) Preclinical Proteinuria
Maze Therapeutics (Originator) Preclinical Renal Disorders
Maze Therapeutics (Originator) Preclinical Renal Disorders
Ionis Pharmaceuticals (Originator)
University of Pennsylvania (Originator)
Preclinical Antisense Therapy
Oligonucleotides
Renal Disorders
University of Georgia (UGA) (Originator) Biological Testing Bispecific Antibody Fusions
Cancer Immunotherapy
Fusion Proteins
Human Monoclonal Antibodies
Polypeptides, from 41 AA
Single-Chain V-Domain Antibody Fragment (scFv)
Cancer
Ionis Pharmaceuticals (Originator) Biological Testing Antisense Therapy
Single-stranded oligodeoxyribonucleotide (DNA)
Renal Disorders

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

If you would like to gain deeper insights into our anti-APOL1 recombinant antibody offerings, please don't hesitate to reach out to us. We are eager to discuss potential partnerships and provide robust support for your research projects.

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