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ARHGAP25

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For Research Use Only. Not For Clinical Use.


ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (granulocytes, NK-cells, B-cells, Microglial cells, T-cells)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (HEL, HMC-1, NB-4, U-266/70)

Molecular function

GTPase activation

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