1 0
Cart
    Inquiry
    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

    Anti-ATP5F1A Recombinant Antibody Products

    Loading...

    Anti-ATP5F1A Products

    + Filter
    Loading...
    View More Products

    Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

    More Infomation

    Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

    For Research Use Only. Not For Clinical Use.


    Support your research into mitochondrial biology and cellular energetics with Creative Biolabs' premium anti-ATP5F1A recombinant antibodies. ATP5F1A is the catalytic alpha subunit of the F1 complex of ATP synthase, a protein complex vital for energy production in all cells. Study mitochondrial function, bioenergetics, and metabolic dysfunction with our reliable and high-quality antibodies.

    ATP5F1A: The Catalytic Core of Cellular Energy Production

    ATP5F1A encodes ATP Synthase Subunit Alpha, a component of the F1 sector of the mitochondrial ATP synthase (also known as Complex V). The F1 sector extends into the mitochondrial matrix and is where ATP synthesis occurs. The alpha subunit is one of the regulatory subunits, but together with the beta subunits it forms the catalytic core. The entire complex uses the proton gradient produced by the electron transport chain to drive the phosphorylation of ADP to ATP, the cell's energy currency. This enzyme is absolutely critical for life.

    Alternative Names

    OMR; ORM; ATPM; MOM2; ATP5A; hATP1; ATP5A1; MC5DN4; ATP5AL2; COXPD22; HEL-S-123m; ATP synthase subunit alpha, mitochondrial; ATP synthase alpha chain, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP sythase (F1-ATPase) alpha subunit; epididymis secretory sperm binding protein Li 123m; mitochondrial ATP synthetase, oligomycin-resistant

    Background

    This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c).

    Protein class

    Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Distal tubular cells, Proximal tubular cells, Cytotrophoblasts, Syncytiotrophoblasts, Extravillous trophoblasts)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Low cell line specificity

    Interaction

    F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c (By similarity). Interacts with ATPAF2 (PubMed:11410595). Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro) (PubMed:19285951). Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin (PubMed:10077593). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with BLOC1S1 (PubMed:22309213). Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficiency (By similarity). Interacts with CLN5 and PPT1 (By similarity). Interacts with S100A1; this interaction increases F1-ATPase activity (By similarity). Interacts with ABCB7; this interaction allows the regulation of cellular iron homeostasis and cellular reactive oxygen species (ROS) levels in cardiomyocytes (By similarity).

    More Types Infomation

    Anti-ATP5F1A rAb Products

    Creative Biolabs' anti-ATP5F1A recombinant antibodies are designed for specificity and strong performance when detecting this crucial mitochondrial protein. The antibodies are thoroughly validated for use in applications like Western Blot to measure mitochondrial content and IHC to visualize mitochondrial distribution in tissues. These rAbs are perfect for use in basic bioenergetics research because they can be relied upon.

    Table 1. Featured anti-ATP5F1A recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    ZG-0560J Rabbit Anti-ATP5F1A Recombinant Antibody (clone 5G11) Human, Mouse Rabbit IgG ELISA, WB, IHC
    VS3-WK551 Rabbit Anti-ATP5F1A Recombinant Antibody (clone JM110-04) Human, Mouse, Rat Rabbit IgG WB, ICC, IF, IHC, FC
    VS7-HM173 Mouse Anti-ATP5F1A Recombinant Antibody (clone 1A5B6) Human Mouse IgG1 WB, IHC, FCM

    Creative Quality Control

    Creative Biolabs is committed to providing the highest quality research tools possible. Our production of anti-ATP5F1A recombinant antibodies is governed by a robust quality assurance process. Every lot of antibodies is thoroughly tested for purity, binding affinity, and consistent performance in validated applications to ensure that you receive a high-quality reagent for your important experiments.

    WB analysis. (Creative Biolabs Original)Fig.1 WB analysis of anti-ATP5F1A antibody
    (Cat# ZG-0560J, Creative Biolabs).

    IHC analysis. (Creative Biolabs Original)Fig.2 IHC analysis of anti-ATP5F1A antibody
    (Cat# ZG-0560J, Creative Biolabs).

    Customer Reviews

    Excellent
    Os**r
    Rabbit Anti-ATP5F1A Recombinant Antibody (clone 5G11)
    Creative Biolabs' anti-ATP5F1A is an excellent mitochondrial marker for our Western blots. The signal is strong, the antibody is specific, and we use it as a loading control for our mitochondrial fractions.
    21/Nov/2024

    rAb Production

    Creative Biolabs is committed to supporting basic research in cell biology by utilizing the latest production platforms. Our anti-ATP5F1A recombinant antibodies are expressed in highly optimized systems to ensure they specifically recognize the native protein in the large ATP synthase complex, providing a specific and active research tool.

    Featured Anti-ATP5F1A Recombinant Antibody Production PlatformsMilligram-scale. (Creative Biolabs Original)
    Fig.3 Milligram-scale anti-ATP5F1A recombinant antibody production.

    Gram-scale. (Creative Biolabs Original)Fig.4 Gram-scale anti-ATP5F1A recombinant antibody production.

    rAb Modalities

    Creative Biolabs is dedicated to enabling scientific discovery by providing customizable antibody solutions in a variety of modalities. Our anti-ATP5F1A recombinant antibodies are available in multiple customizable formats to meet the needs of a variety of experimental approaches, empowering researchers across the globe to study the central machinery of cellular energy production.

    ATP5F1A antibody production and modalities. (Creative Biolabs Original)Fig.5 Full-length anti-ATP5F1A recombinant antibody production and modalities.

    Study the process of ATP synthesis with Creative Biolabs' high-quality anti-ATP5F1A recombinant antibodies. Our selection is defined by its high specificity and thorough validation to provide the perfect tools for your research. Partner with us for quality you can count on. Contact our experts today.

    100
    Go to compare

    Go to compare