Anti-ATP7A Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a front-runner in rare disease and neuroscience research, with the most elite anti-ATP7A recombinant antibodies in the industry. The protein ATP7A, a copper-transporting ATPase which provides copper to the brain and other tissues, is mutated in Menkes disease. Our premium antibodies are powerful tools for diagnosis of this condition, and for studying the basic biology of copper transport in the secretory pathway.

ATP7A: The Menkes Disease Copper Transporter

ATP7A is a large multi-pass membrane protein and copper transporting P-type ATPase. It primarily localizes to the trans-Golgi Network (TGN) in most cell types (except the liver). The protein’s main function is to pump copper from the cytosol into the TGN to load onto copper dependent enzymes en route to secretion (e.g., lysyl oxidase for collagen). Upon reaching a certain intracellular copper threshold, ATP7A is able to dynamically relocate from the TGN to the plasma membrane to actively pump copper out of the cell. Loss-of-function mutations in ATP7A underlie Menkes disease, a fatal, neurodegenerative disorder of copper deficiency.

Alternative Names

ATPase Copper Transporting Alpha; ATPase, Cu++ Transporting, Alpha Polypeptide; Copper Pump 1; Menkes Disease-Associated Protein; MNK; Cu++-Transporting P-Type ATPase; Copper-Transporting ATPase 1; Menkes Syndrome; EC 3.6.3.54; EC 3.6.3.4; EC 3.6.3; DSMAX; SMAX3; MC1; MK

Background

ATP7A (ATPase Copper Transporting Alpha) is a Protein Coding gene. This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. Diseases associated with ATP7A include Menkes Disease and Occipital Horn Syndrome.

Anti-ATP7A rAb Products

Our anti-ATP7A recombinant antibodies are engineered for high specificity and robust performance. Validated extensively to ensure reliable detection of this large membrane protein. Optimized for use in Western Blot to diagnose Menkes disease (detected as absent or truncated protein) and immunofluorescence to visualize the dynamic, copper dependent trafficking of ATP7A from the TGN to plasma membrane.

Table 1. Featured anti-ATP7A recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs employs advanced production technologies to speed up the race to discovery in neurobiology. Our anti-ATP7A recombinant antibodies are carefully developed and screened to ensure high affinity recognition of this challenging transmembrane protein, ideal for demanding applications.

Featured Anti-ATP7A Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ATP7A recombinant antibody production.

Fig.2 Gram-scale anti-ATP7A recombinant antibody production.

rAb Modalities

Creative Biolabs is proud to offer flexible and innovative tools for the research community. Our anti-ATP7A antibodies can be obtained in a variety of modalities to meet your needs and support a diverse set of experimental applications, for researchers around the world.

Fig.3 Full-length anti-ATP7A recombinant antibody production and modalities.

Power your Menkes disease research with Creative Biolabs’ superior anti-ATP7A recombinant antibodies. Our portfolio is designed for uncompromising specificity and validated for consistent performance across diagnostics and cell biology applications. Place your trust in our expertise. Talk to our specialists today.