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Anti-ATP7B Recombinant Antibody Products

Anti-ATP7B Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs provides clients worldwide with a diverse range of ATP7B-targeted recombinant antibodies through our advanced platforms. Our dedication to advancing research and discovery is backed up by exceptional value and unrivaled technical support, allowing our clients to achieve their scientific objectives efficiently.

ATP7B: A Promising Target in Wilson Disease

The ATP7B protein, found in the trans-Golgi network of the liver and brain, plays a crucial role in maintaining copper homeostasis by facilitating the excretion of excess copper into bile and plasma. Mutations in the ATP7B gene often lead to Wilson's disease, a genetic disorder characterized by the accumulation of copper in tissues. This accumulation can result in severe neurological or psychiatric symptoms, liver disease, and can be fatal if not treated. Due to the essential function of ATP7B in copper regulation, it presents a promising target for the development of specific therapeutics aimed at treating Wilson’s disease.

Alternative Names

Wilson disease protein; WND; PWD; WC1; WD; ATPase copper transporting beta; Copper Pump 2; Copper-Transporting ATPase 2; ATPase, Cu++ Transporting, Beta Polypeptide; Wilson Disease-Associated Protein; ATPase, Cu++ Transporting, Beta Polypeptide (Wilson Disease); ATPase Cu(2+)- Transporting Beta Polypeptide; Copper-Transporting Protein ATP7B; Wilson Disease; EC 7.2.2.8; EC 3.6.3.4; EC 3.6.3.

Background

This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Late spermatids, Early spermatids, Inhibitory neurons, Excitatory neurons, Hepatocytes, Cone photoreceptor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, CACO-2, HEL, RPTEC TERT1)

Interaction

Monomer. Interacts with COMMD1/MURR1 (PubMed:12968035, PubMed:17919502). Interacts with DCTN4, in a copper-dependent manner (PubMed:16554302). Interacts with ATOX1 (PubMed:18558714, PubMed:17919502). Interacts (via C-terminus) with ZBTB16/PLZF (PubMed:16676348).

Molecular function

Translocase

More Types Infomation

Anti-ATP7B Recombinant Antibody Products

We are dedicated to advancing research and innovation by providing high-quality anti-ATP7B recombinant antibodies at excellent value, along with comprehensive technical support. Here are some recombinant antibodies that target ATP7B. To get all the details and choose the optimal choice, kindly click on the provided link.

Cat. No. Product Name Target Species Host Species Applications
NABG-020 Recombinant Anti-Human ATP7B VHH Single Domain Antibody Human Llama VHH WB, ELISA, IHC, FS, etc.
MOB-0857MZ Mouse Anti-ATP7B Recombinant Antibody (clone CBLS-150) Human Mouse IgG1 WB
MOR-0300 Hi-Affi™ Rabbit Anti-ATP7B Recombinant Antibody (clone DS300AB) Human Rabbit IgG WB, ICC, FC

Creative Quality Control

Our mission is to improve the biopharmaceutical industry by offering high-quality products and excellent customer service. Through our stringent quality management system, we ensure that our offerings not only meet but also exceed industry standards. This commitment to excellence improves drug development efficiency while also providing our clients with unrivaled value and reliability.

Customer Reviews

Excellent
Sv***a
Recombinant Anti-Human ATP7B VHH Single Domain Antibody (CAT#: NABG-020)
Application: Immunocytochemistry experiments in polarized hepatocellular carcinoma cell lines.
The antibody delivered precise staining, with minimal interference from background noise. This made it effortless to identify the exact localization of ATP7B within the cells. What's more, the results remained consistent across multiple trials, which further validated the reliability of this antibody. I also found the accompanying documentation to be incredibly detailed and useful in optimizing my experimental protocol.
21/Sep/2023
Excellent
Pe***i
Mouse Anti-ATP7B Recombinant Antibody (clone CBLS-150) (CAT#: MOB-0857MZ)
Experiment: WB
Sample: Human iPS cells differentiated into neurons
I employ the Mouse Anti-ATP7B Recombinant Antibody to detect the expression level in the sample after treatment. I noticed a strong positive signal on my PVDF membrane. The dilution and loading amount of the sample are consistent with Creative Biolabs' suggestion. They are professional and their products are reliable.
14/Mar/2024
Excellent
Elo**a
Hi-Affi™ Rabbit Anti-ATP7B Recombinant Antibody (clone DS300AB) (CAT#: MOR-0300)
I bought the anti-ATP7B recombinant antibody from Creative Biolabs to detect ATP7B knockdown in head and neck squamous cell carcinomas cells. I was thrilled to see a robust and specific positive signal in my results, which propelled my research to the next level.
1/Dec/2023

Anti-ATP7B Recombinant Antibody Production

Our state-of-the-art mammalian cell expression platform is designed to be serum-free. We provide a full range of services, including gene synthesis and scalable, high-quality anti-ATP7B recombinant antibody production. A combination of our five years of process optimization experience, we efficiently and affordably provide solutions for different quantities of antibodies.

Featured Anti-ATP7B Recombinant Antibody Production Platforms Fig.1 Anti-ATP7B recombinant antibody production: Milligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale anti-ATP7B recombinant antibody production.

Fig.2 Anti-ATP7B recombinant antibody production: Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-ATP7B recombinant antibody production.

Anti-ATP7B Recombinant Antibody Modalities

Creative Biolabs offers a wide range of premium anti-ATP7B recombinant antibodies in different formats, including full-length, Fab, scFv, and more. With our deep knowledge and vast experience in antibody engineering, we are fully equipped to offer tailored solutions that perfectly align with clients’ unique research requirements.

Fig.3 The production and modalities of full-length anti-ATP7B recombinant antibody. (Creative Biolabs Original)Fig.3 Full-Length Anti-ATP7B Recombinant Antibody Production and Modalities.

ATP7B-Targeted Drug Information

Table 1. ATP7B-targeted drug information.

Company Highest Phase Classification Condition
Ultragenyx (Originator) Phase I/II Adeno-Associated Viral (AAV) Vectors
Gene Therapy
Wilson's disease
Pfizer
Vivet Therapeutics (Originator)
Phase I/II Adeno-Associated Viral (AAV) Vectors
Gene Therapy
Wilson's disease
Skyline Therapeutics (Originator) Preclinical Adeno-Associated Viral (AAV) Vectors
Gene Therapy
Wilson's disease
West China Hospital of Sichuan University (Originator) Preclinical Adeno-Associated Viral (AAV) Vectors
Gene Therapy
Wilson's disease
Shanghai Jiao Tong University (SJTU) (Originator) Preclinical Adeno-Associated Viral (AAV) Vectors
CRISPR/Cas9 System Nucleases
Gene Therapy
Single Guide RNA (sgRNA)
Single-stranded oligoribonucleotide (RNA)
Genetic Disorders
Aligen Therapeutics (Originator)
Centro Investigacion Medica Aplicada (Originator)
Universidad de Navarra (Originator)
Preclinical Adeno-Associated Viral (AAV) Vectors
Gene Therapy
Wilson's disease
Nanjing First Hospital (Originator) Preclinical Mesenchymal Stem Cells
Stem Cell-Based Gene Therapy
Stem Cell Therapy
Wilson's disease
Children's Hospital of Philadelphia (Originator) Preclinical Gene Therapy Wilson's disease
Oxford BioMedica (Originator) Biological Testing Gene Therapy
Lentiviral Vectors
Wilson's disease

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

If you have any further questions about our anti-ATP7B recombinant antibody products, please contact us as soon as possible. We are excited about the prospect of identifying potential collaborative partnerships that will benefit both parties and advance your research.

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